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[流感与死亡。高死亡率不仅归因于大规模流行]

[Influenza and death. High mortality not only due to the great epidemics].

作者信息

Grandien M, Nilsson A, Hambraeus L

机构信息

Virologiska Avdelningen, Statens Bakteriologiska Laboratorium, Stockholm.

出版信息

Lakartidningen. 1991 Mar 6;88(10):854-9.

PMID:2008131
Abstract

Excess mortality in a population is one of the hallmarks of an influenza epidemic. Apart from the pandemic years, 1918-1919, 1957 and 1968-1969, annual excess mortality has occurred 16 times in Sweden during the period 1911-1988. An unusually high mortality was caused by Influenza A Sichuan 2/87 (H3N2), the unexpected appearance of which at the beginning of November 1988 started an intensive epidemic in Sweden, while other European countries had a relatively mild influenza season. Swedish deaths in December totalled 10,500-2,200 more than expected; age groups over 65 years accounted for 95 per cent of the mortality, and those over 80 (N = 350,000 in Sweden) for 1,400 deaths. 0.4 percent of those over 80 died. The excess mortality is to be explained by the high proportion of the elderly in the Swedish population and the very low rate of influenza vaccination before the outbreak. As the increase in the proportion of the very elderly can be expected to continue, future influenza epidemics will result in even higher mortality unless adequate prophylactic measures are taken.

摘要

人群中的超额死亡率是流感流行的标志之一。除了大流行年份(1918 - 1919年、1957年和1968 - 1969年)外,在1911 - 1988年期间,瑞典每年都出现过16次超额死亡率。甲型四川2/87(H3N2)流感导致了异常高的死亡率,它于1988年11月初意外出现,在瑞典引发了一场严重的疫情,而其他欧洲国家的流感季节相对温和。12月瑞典的死亡人数比预期多了10,500 - 2,200人;65岁以上年龄组占死亡人数的95%,80岁以上(瑞典有35万人)有1400人死亡。80岁以上人群中有0.4%的人死亡。超额死亡率可归因于瑞典人口中老年人比例高以及疫情爆发前流感疫苗接种率极低。由于预计高龄人群的比例还会继续增加,除非采取充分的预防措施,未来的流感疫情将导致更高的死亡率。

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