Vitoratos Nikolaos, Dimitrakaki Alexandra, Vlahos Nikolaos F, Gregoriou Odysseas, Panoulis Kostantinos, Christopoulos Panagiotis, Creatsas George
2nd Department of Obstetric and Gynecology, School of Medicine, University of Athens, Aretaieion University Hospital, 76 Vas. Sofias Av., Athens, Greece.
J Matern Fetal Neonatal Med. 2010 Sep;23(9):1019-23. doi: 10.3109/14767050903551459.
To evaluate the role of resistin in the pathophysiology of insulin resistance during pregnancy and on the birth weight of infants born from women with gestational diabetes (GDM).
Thirty women diagnosed with GDM were compared to 30 normal pregnant controls. Maternal serum resistin and insulin levels were measured at the time of the oral glucose tolerance test screening. In addition, umbilical levels of resistin and insulin were measured at the time of delivery.
There was no difference in maternal serum resistin levels in women with GDM as compared to normal controls at 24-26 weeks. There was no difference in umbilical resistin levels between the infants born in the two groups. There was no correlation between infant weight and either maternal resistin at 24-26 week or umbilical resistin levels.
There were no significant differences in umbilical resistin levels between infants born of women with GDM as compared to normal pregnant women. In addition, there was no correlation between resistin levels during pregnancy, as well as between umbilical resistin levels and neonatal birth weight. In conclusion, resistin seems to play a rather minor role in the pathophysiology of GDM and the energy metabolism during fetal life.
评估抵抗素在妊娠期胰岛素抵抗病理生理过程中以及对妊娠期糖尿病（GDM）女性所分娩婴儿出生体重的作用。
将30例诊断为GDM的女性与30例正常妊娠对照者进行比较。在口服葡萄糖耐量试验筛查时测定母体血清抵抗素和胰岛素水平。此外，在分娩时测定脐血抵抗素和胰岛素水平。
在24 - 26周时，GDM女性的母体血清抵抗素水平与正常对照者相比无差异。两组所分娩婴儿的脐血抵抗素水平无差异。婴儿体重与24 - 26周时的母体抵抗素或脐血抵抗素水平均无相关性。
与正常孕妇相比，GDM女性所分娩婴儿的脐血抵抗素水平无显著差异。此外，孕期抵抗素水平之间以及脐血抵抗素水平与新生儿出生体重之间均无相关性。总之，抵抗素似乎在GDM的病理生理过程以及胎儿期能量代谢中起相当小的作用。
