绝经后妇女骨密度降低与亚临床动脉粥样硬化的关系。

Relationship between decreased bone mineral density and subclinical atherosclerosis in postmenopausal women.

机构信息

Department of Physical Medicine and Rehabilitation, Ankara Physical Medicine and Rehabilitation Education and Research Hospital, Ankara, Turkey.

出版信息

Climacteric. 2010 Jun;13(3):254-8. doi: 10.3109/13697130903291041.

DOI:10.3109/13697130903291041

PMID:20082602

Abstract

OBJECTIVES

The study aimed to compare measurements of coronary artery calcification (CAC) and bone mineral density (BMD) in postmenopausal women.

METHODS

The CAC of the women was measured with electron beam tomography using a GE Imatron C150 XP EBT scanner. Subjects with calcium scores above 0 were classified as CAC(+); those without detectable coronary calcium were classified as CAC(-). BMD was measured by dual-energy X-ray absorptiometry (DEXA). Patients were divided into two groups, depending on the T scores of their lumbar spine, into those with normal bone and those with osteopenia-osteoporosis.

RESULTS

The proportions of patients classified as CAC(+) were 20% in the normal group and 60% in the osteopenia-osteoporosis group (p = 0.037). BMD values in L1-4 were 1.13 +/- 2.29 and 0.98 +/- 2.79 g/cm(2) in the normal group and osteopenia-osteoporosis group, respectively and the mean total CAC scores were 1.34 +/- 1.2 and 69.0 +/- 20.5, respectively. The CAC scores of patients with osteopenia-osteoporosis were significantly higher compared with those of the normal group (p = 0.014).

CONCLUSION

The study shows that postmenopausal women with decreased bone mineral density may have higher risk of subclinical coronary atherosclerosis.

摘要

目的

本研究旨在比较绝经后妇女冠状动脉钙化（CAC）和骨密度（BMD）的测量值。

方法

使用 GE Imatron C150 XP EBT 扫描仪的电子束断层扫描测量女性的 CAC。CAC 评分高于 0 的患者被归类为 CAC(+)；未检测到冠状动脉钙的患者被归类为 CAC(-)。通过双能 X 射线吸收法（DEXA）测量 BMD。根据腰椎 T 评分，患者分为两组，一组为骨密度正常，一组为骨质疏松-骨量减少。

结果

在正常组中，被归类为 CAC(+)的患者比例为 20%，在骨质疏松-骨量减少组中为 60%（p = 0.037）。L1-4 的 BMD 值在正常组和骨质疏松-骨量减少组分别为 1.13 +/- 2.29 和 0.98 +/- 2.79 g/cm(2)，平均总 CAC 评分分别为 1.34 +/- 1.2 和 69.0 +/- 20.5。骨质疏松-骨量减少组患者的 CAC 评分明显高于正常组（p = 0.014）。