Xu Rui, Yang Hong-Ni, Li Yu-Qing, Wang Qing-Fang, Guo Ai-Hua, Ayiti Aliya, Chen Xin-Chun, Gong Rui, Banu Guli, Jian Li-Dang, Gao Yun, Sheng Ke, Maimti Yasinjan
No. 4 Department of Health Care for Cadres, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.
Coron Artery Dis. 2016 Nov;27(7):586-91. doi: 10.1097/MCA.0000000000000402.
Atherosclerosis and osteoporosis (OP) are common diseases in elderly individuals and may share common pathogenetic mechanisms. The aim of this study was to investigate the association between bone mineral density (BMD) and coronary artery calcium (CAC) in postmenopausal women.
In this cross-sectional study, 186 postmenopausal women 50-80 years of age were included. BMD of the spine and femoral neck was measured by dual-energy X-ray absorptiometry. The coronary artery calcium score (CACS) was measured by multidetector computed tomography.
The study included postmenopausal women aged 65.6±7.3 years, 109 of whom (58.6%) showed CAC. Thirty-three (17.7%) of the patients were found to have OP in the lumbar spine and 83 (44.6%) had osteopenia, whereas in the femoral neck, 26 patients (14.0%) had OP and 87 patients (46.8%) had osteopenia. The mean CACS was 57.6±108.3 in normal status, 89.7±143.5 in OP, and 156.4±256.9 in osteopenia at the spine (P<0.05). The mean CACS was 43.2±89.9 in normal status, 126.9±180.3 in OP, and 198.2±301.2 in osteopenia at the femoral neck (P<0.05). Multivariable logistic regression analysis showed that BMD was an independent marker for an increased risk of developing CAC in postmenopausal women. The multiple regression model showed that T-scores were the independent predictors of CACS.
BMD identified on images from dual-energy X-ray absorptiometry were strongly related to multidetector computed tomography measures of CAC. This low-cost, minimal radiation technique used widely for OP screening is a promising marker of generalized coronary atherosclerosis.
动脉粥样硬化和骨质疏松症（OP）是老年人的常见疾病，可能具有共同的发病机制。本研究旨在调查绝经后女性骨密度（BMD）与冠状动脉钙化（CAC）之间的关联。
在这项横断面研究中，纳入了186名年龄在50 - 80岁的绝经后女性。采用双能X线吸收法测量脊柱和股骨颈的骨密度。通过多排螺旋计算机断层扫描测量冠状动脉钙化评分（CACS）。
该研究纳入了年龄为65.6±7.3岁的绝经后女性，其中109名（58.6%）显示有CAC。33名（17.7%）患者腰椎存在OP，83名（44.6%）有骨量减少；而在股骨颈，26名患者（14.0%）有OP，87名患者（46.8%）有骨量减少。在脊柱，正常状态下平均CACS为57.6±108.3，OP患者为89.7±143.5，骨量减少患者为156.4±256.9（P<0.05）。在股骨颈，正常状态下平均CACS为43.2±89.9，OP患者为126.9±180.3，骨量减少患者为198.2±301.2（P<0.05）。多变量逻辑回归分析表明，BMD是绝经后女性发生CAC风险增加的独立标志物。多元回归模型显示，T值是CACS的独立预测因子。
双能X线吸收法图像上识别出的BMD与多排螺旋计算机断层扫描测量的CAC密切相关。这种广泛用于OP筛查的低成本、低辐射技术是全身性冠状动脉粥样硬化的一个有前景的标志物。
