School of Nursing, Clinical Trials Research Unit, University of Auckland, Auckland, New Zealand.
Wound Repair Regen. 2010 Jan-Feb;18(1):26-30. doi: 10.1111/j.1524-475X.2009.00556.x.
The aim of the study was to evaluate the responsiveness of the Short Form Health Survey, the EuroQol 5 Dimension questionnaire, and the Charing Cross Venous Ulcer Questionnaire (CXVUQ) to venous ulcer healing. Participants had health-related quality of life measured at baseline and 12 weeks. Standardized response means were calculated to assess the responsiveness of the instruments to change in an ulcer state (healed vs. unhealed). Three hundred and sixty-eight participants completed the questionnaires at baseline and 360 at 12 weeks. One hundred and ninety-three participants (54%) had healed at 12 weeks. The standardized response means ranged from -0.01 to 0.47 for Short Form Health Survey, 0.10-0.31 for EuroQol 5 Dimension questionnaire, and -0.21 to -0.92 for CXVUQ. Differences between healed and unhealed participants at 12 weeks were significantly different for three of the eight domains on Short Form Health Survey and on all domains for the CXVUQ. There were no significant differences between the groups on the EuroQol 5 Dimension questionnaire scales. CXVUQ was more responsive than the generic instruments to change in ulcer status over 12 weeks for measuring health-related quality of life of patients with venous ulceration.
这项研究的目的是评估简短健康调查量表、欧洲五维健康量表问卷和查尔灵十字静脉溃疡问卷（CXVUQ）对静脉溃疡愈合的反应能力。参与者在基线和 12 周时测量了与健康相关的生活质量。计算了标准化反应均值，以评估这些工具对溃疡状态（愈合与未愈合）变化的反应能力。368 名参与者在基线时完成了问卷，360 名参与者在 12 周时完成了问卷。193 名参与者（54%）在 12 周时愈合。标准化反应均值在简短健康调查量表中为-0.01 至 0.47，在欧洲五维健康量表问卷中为 0.10-0.31，在 CXVUQ 中为-0.21 至-0.92。在 12 周时，愈合组和未愈合组在简短健康调查量表的八个领域中的三个领域以及 CXVUQ 的所有领域的得分存在显著差异。在欧洲五维健康量表问卷的量表上，两组之间没有显著差异。在测量静脉溃疡患者健康相关生活质量方面，CXVUQ 比通用工具对 12 周内溃疡状态的变化更敏感。
