Clinic for Preventive Dentistry, Periodontology and Cariology, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland.
Arch Oral Biol. 2010 Mar;55(3):223-8. doi: 10.1016/j.archoralbio.2009.11.007. Epub 2010 Jan 18.
This in situ study aimed to analyse the impact of different tetrafluorides (TiF(4), ZrF(4) and HfF(4)) and AmF on erosion and erosion plus abrasion of enamel and dentin.
Ten volunteers took part in this crossover and double-blind study performed in 8 phases of each 3 days. In each phase, 2 bovine enamel and 2 dentin specimens were fixed in intraoral appliances. One enamel and one dentin sample were pretreated once with TiF(4), ZrF(4), HfF(4) or AmF (all 0.5M F) for 60s, while the other samples remained unfluoridated and served as control. Then, all samples were subjected to either erosion only (4 times/day, 90 s) or to erosion and abrasion (2 times/day, 30 s/sample). Toothbrushing abrasion was performed 90 min after the first and last erosion with an electrical toothbrush and fluoridated toothpaste at 1.2N. After 3 days, enamel and dentin loss was assessed by profilometry (microm) and analysed by repeated measures ANOVA and paired t-test (p<0.05).
All fluoride solutions reduced enamel and dentin loss significantly compared to the controls. Generally, eroded samples showed less wear than eroded and abraded samples. The protective potential of the fluorides was not significantly different and was only slightly, but mostly not significantly, decreased by abrasion. The protective effect of the fluoride solutions was similar in enamel and dentin.
Tetrafluorides and AmF are able to reduce erosion and erosion plus abrasion in situ and are almost equally effective.
本原位研究旨在分析不同四氟化物（TiF4、ZrF4和 HfF4）和 AmF 对牙釉质和牙本质侵蚀及侵蚀加磨损的影响。
十名志愿者参加了这项交叉和双盲研究，共分为 8 个阶段，每个阶段持续 3 天。在每个阶段，2 个牛牙釉质和 2 个牙本质样本被固定在口腔内器械中。一个牙釉质和一个牙本质样本用 TiF4、ZrF4、HfF4或 AmF（均为 0.5M F）预处理一次 60s，而其他样本未氟化，作为对照。然后，所有样本仅进行侵蚀（每天 4 次，每次 90s）或侵蚀加磨损（每天 2 次，每次 30s/sample）。第一次和最后一次侵蚀后 90min，用电动牙刷和含氟牙膏以 1.2N 进行牙刷牙磨损。3 天后，通过轮廓测量（微米）评估牙釉质和牙本质的损失，并通过重复测量方差分析和配对 t 检验进行分析（p<0.05）。
与对照组相比，所有氟化物溶液均显著减少了牙釉质和牙本质的损失。一般来说，与侵蚀加磨损的样本相比，仅侵蚀的样本磨损较少。氟化物的保护潜力没有显著差异，仅略微但大多不显著地被磨损所降低。氟化物溶液在牙釉质和牙本质中的保护效果相似。
四氟化物和 AmF 能够在体内减少侵蚀和侵蚀加磨损，效果几乎相同。
