Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil.
Int J Paediatr Dent. 2012 Jan;22(1):11-6. doi: 10.1111/j.1365-263X.2011.01151.x. Epub 2011 Jun 20.
OBJECTIVE. Previous in vitro study has shown that TiF(4) varnish might reduce enamel erosion. No data regarding the effect of this experimental varnish on enamel erosion plus abrasion, however, are available so far. Thus, this in vitro study aimed to analyse the effect of TiF(4) compared with NaF varnishes and solutions, to protect against enamel erosion with or without abrasion. METHODS. Enamel specimens were pre-treated with experimental-TiF(4) (2.45% F), experimental-NaF (2.45% F), NaF-Duraphat (2.26% F), and placebo varnishes; NaF (2.26% F) and TiF(4) (2.45% F) solutions. Controls remained untreated. The erosive challenge was performed using a soft drink (pH 2.6) 4 × 90 s/day (ERO) and the toothbrushing abrasion (ERO+ABR) 2 × 10 s/day, for 5 days. Between the challenges, the specimens were exposed to artificial saliva. Enamel loss was measured profilometrically (μm). RESULTS. Kruskal-Wallis/Dunn tests showed that all fluoridated varnishes (TiF(4) -ERO:0.53 ± 0.20, ERO+ABR:0.65 ± 0.19/NaF-ERO:0.94 ± 0.18, ERO+ABR:1.74 ± 0.37/Duraphat-ERO:1.00 ± 0.37, ERO+ABR:1.72 ± 0.58) were able to significantly reduce enamel loss when compared with placebo varnish (ERO:3.45 ± 0.41/ERO+ABR:3.20 ± 0.66) (P < 0.0001). Placebo varnish, control (ERO:2.68 ± 0.53/ERO+ABR:3.01 ± 0.34), and fluoridated (NaF-ERO:2.84 ± 0.09/ERO+ABR:2.40 ± 0.21/TiF(4) -ERO:3.55 ± 0.59/ERO+ABR:4.10 ± 0.38) solutions did not significantly differ from each other. CONCLUSION. Based on the results, it can be concluded that the TiF(4) varnish seems to be a promising treatment to reduce enamel loss under mild erosive and abrasive conditions in vitro.
目的。先前的体外研究表明 TiF(4) 涂料可能减少牙釉质侵蚀。然而，目前尚无关于这种实验性涂料对牙釉质侵蚀加磨损的影响的数据。因此，本体外研究旨在分析 TiF(4) 与 NaF 涂料和溶液相比，对预防有或无磨损的牙釉质侵蚀的效果。方法。使用实验性 TiF(4)（2.45% F）、实验性 NaF（2.45% F）、NaF-Duraphat（2.26% F）和安慰剂涂料；NaF（2.26% F）和 TiF(4)（2.45% F）溶液预处理牙釉质标本。对照组不做任何处理。使用软饮料（pH 2.6）进行侵蚀性挑战 4×90 s/天（ERO）和牙刷牙膏磨损（ERO+ABR）2×10 s/天，共 5 天。在挑战之间，标本暴露于人工唾液中。使用轮廓测量法测量牙釉质损失（μm）。结果。Kruskal-Wallis/Dunn 检验显示，所有氟化涂料（TiF(4)-ERO：0.53±0.20，ERO+ABR：0.65±0.19/NaF-ERO：0.94±0.18，ERO+ABR：1.74±0.37/Duraphat-ERO：1.00±0.37，ERO+ABR：1.72±0.58）与安慰剂涂料（ERO：3.45±0.41/ERO+ABR：3.20±0.66）相比，均能显著减少牙釉质损失（P<0.0001）。安慰剂涂料、对照组（ERO：2.68±0.53/ERO+ABR：3.01±0.34）和氟化（NaF-ERO：2.84±0.09/ERO+ABR：2.40±0.21/TiF(4)-ERO：3.55±0.59/ERO+ABR：4.10±0.38）溶液之间无显著差异。结论。根据结果，可以得出结论，TiF(4) 涂料似乎是一种有前途的治疗方法，可以减少体外轻度侵蚀和磨损条件下的牙釉质损失。
