arc Epidemiology Unit, Manchester Academy of Health Sciences, The University of Manchester, Manchester, UK.
Curr Opin Rheumatol. 2010 Mar;22(2):152-6. doi: 10.1097/BOR.0b013e32833669d2.
Psoriatic arthritis (PsA) has a large genetic component to its heritability, yet investigation into the genetic basis of the disease has lagged behind other rheumatic diseases mainly because of the difficulty in defining classification criteria that would accurately differentiate it from other forms of inflammatory arthritis. However, using a variety of approaches, some confirmed associations have now been identified with PsA susceptibility, making a review of these recent developments timely.
Family studies continue to suggest a large genetic contribution to PsA. Using a candidate gene approach, genes robustly confirmed to be associated with psoriasis vulgaris (PsV) have also been found to be associated with PsA (HLA-Cw*0602, IL23R, IL12B). There is less overlap reported with rheumatoid arthritis (RA) than PsV susceptibility loci but one report suggests that the AFF3 locus may be associated with both RA and PsA.
Large, well powered genome-wide association studies are currently underway and should provide further insights into the cause of this common arthritic disease over the next few months. The bulk of evidence so far suggests that the genetic factors underlying PsV are also associated with PsA suggesting that future studies of PsV could include patients with PsA.
银屑病关节炎（PsA）具有很大的遗传因素，但其遗传基础的研究落后于其他风湿性疾病，主要是因为难以确定能够准确将其与其他形式的炎性关节炎区分开来的分类标准。然而，通过多种方法，现在已经确定了一些与 PsA 易感性相关的明确关联，因此及时对这些最新进展进行综述是有必要的。
家族研究继续表明 PsA 具有很大的遗传贡献。使用候选基因方法，与寻常型银屑病（PsV）强相关的基因也被发现与 PsA 相关（HLA-Cw*0602、IL23R、IL12B）。与类风湿关节炎（RA）相比，报告的重叠较少，但有一项报告表明，AFF3 基因座可能与 RA 和 PsA 都相关。
目前正在进行大型、功能强大的全基因组关联研究，应该能够在未来几个月内提供更多关于这种常见关节炎疾病病因的见解。到目前为止，大部分证据表明，导致 PsV 的遗传因素也与 PsA 相关，这表明未来对 PsV 的研究可以包括患有 PsA 的患者。
