Vigeh Mohsen, Yokoyama Kazuhito, Matsukawa Takehisa, Shinohara Atsuko, Shariat Mamak, Ohtani Katsumi
Maternal, Fetal & Neonatal Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Dept. of Epidemiology and Environmental Health, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-Ku, Tokyo, Japan.
Iran J Public Health. 2017 Aug;46(8):1018-1027.
Although the level of exposure to many toxic metals decreased recently, the adverse effects of these metals on children's growth and development remain a serious public health issue.
The present study was conducted in three teaching hospitals affiliated with Tehran University of Medical Sciences (Tehran, Iran) from Sep 2012 to Mar 2013. To study the relationship between metals and childhood growth, concentrations of zinc and several potentially toxic metals (lead, cadmium, antimony, cobalt, and molybdenum) were measured in scalp hair for 174 children, aged 20 to 36 months.
The hair concentrations of cobalt were significantly (<0.05) higher in children at the lower percentile of weight than in higher-weight children (0.026 ± 0.04 vs. 0.015 ± 0.01 μg/g, respectively). Hair contents of lead, cobalt, and antimony were significantly higher (<0.05) in girls than in boys (8.08 ± 8.7 vs. 4.92 ± 5.6 μg/g for lead, 0.026 ± 0.03 vs. 0.16 ± 0.02 μg/g for cobalt, and 0.188 ± 0.29 vs. 0.102 ± 0.12 μg/g for antimony). There were also significant correlations between lead and other metals in the children's hair.
Gender may play a significant role in absorption and/or accumulation of metals. It should be considered when we study metal toxicity in children.
尽管近期许多有毒金属的暴露水平有所下降，但这些金属对儿童生长发育的不良影响仍是一个严重的公共卫生问题。
本研究于2012年9月至2013年3月在德黑兰医科大学附属的三家教学医院（伊朗德黑兰）进行。为研究金属与儿童生长之间的关系，对174名年龄在20至36个月的儿童的头皮头发中锌和几种潜在有毒金属（铅、镉、锑、钴和钼）的浓度进行了测量。
体重百分位数较低的儿童头发中的钴浓度显著（<0.05）高于体重较高的儿童（分别为0.026±0.04与0.015±0.01μg/g）。女孩头发中的铅、钴和锑含量显著（<0.05）高于男孩（铅为8.08±8.7与4.92±5.6μg/g，钴为0.026±0.03与0.16±0.02μg/g，锑为0.188±0.29与0.102±0.12μg/g）。儿童头发中的铅与其他金属之间也存在显著相关性。
性别可能在金属的吸收和/或积累中起重要作用。在研究儿童金属毒性时应予以考虑。
