Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Arq Bras Cardiol. 2009 Nov;93(5):561-8. doi: 10.1590/s0066-782x2009001100019.
One of the most recent phenomena related to the acquired immunodeficiency syndrome (AIDS) is the emergence of a new vulnerable population: the elderly. One of the factors that account for this increase is the development of combination antiretroviral therapy (ART), which has provided better quality of life and life expectancy for HIV-positive patients. However, ART is associated with adverse effects such as dyslipidemia, diabetes mellitus and insulin resistance, which are risk factors for cardiovascular disease. Due to the impact of ART on lipid and glucose metabolism, many studies were published involving HIV infection and cardiovascular disease, as well as their risk factors and the use of ART, but few of them reported on the cardiotoxicity of this therapy in the elderly. The objective of this study is to review the main metabolic changes caused by the use of antiretroviral therapy and its impact on an increased risk of cardiovascular disease in elderly people with HIV.
与获得性免疫缺陷综合征（AIDS）相关的最新现象之一是出现了一个新的弱势群体：老年人。导致这一增长的因素之一是联合抗逆转录病毒疗法（ART）的发展，它为 HIV 阳性患者提供了更好的生活质量和预期寿命。然而，ART 与血脂异常、糖尿病和胰岛素抵抗等不良反应相关，这些都是心血管疾病的危险因素。由于 ART 对脂质和葡萄糖代谢的影响，许多涉及 HIV 感染和心血管疾病及其危险因素以及 ART 使用的研究发表，但很少有研究报告该疗法对老年人的心脏毒性。本研究的目的是综述抗逆转录病毒治疗引起的主要代谢变化及其对 HIV 老年患者心血管疾病风险增加的影响。
