Research Center for Genes, Environment, and Human Health, and Institute of Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan, ROC.
Cancer Causes Control. 2010 May;21(5):771-6. doi: 10.1007/s10552-010-9505-x. Epub 2010 Jan 19.
It has been widely accepted that sun exposure is a risk factor of squamous cell carcinoma (SCC) among fair-skinned populations. However, sun exposure and sun reaction have not been explored in Asians and no gender-specific data were available.
In a case-control study, 176 incident skin cancer cases were recruited from National Cheng-Kung University Medical Center from 1996 to 1999. Controls included 216 age-, gender-, and residency-matched subjects from the southwestern Taiwan. A questionnaire was administered to collect information on life style and other risk factors. Logistic regression analysis was performed to evaluate the association between sun exposure or sun reaction and the risk of SCC by gender.
Early-age (age 15 to 24) and lifetime sun exposure were significantly associated with increased risk of SCC in a dose-response pattern [odds ratio (OR) = 1.49-3.08, trend p = 0.009 and 0.0007, respectively]. After stratified by gender, the third tertile of early-age sun exposure was significantly associated with the SCC risk among men (OR = 3.08). The second and third tertiles of lifetime sun exposure was significantly associated with SCC risk among women (OR = 3.78 and 4.53, respectively). Skin reaction after 2-h sun exposure during childhood and adolescence was not significantly associated with the risk of SCC.
Lifetime sun exposure was more related to SCC risk in women, while early-age sun exposure was more relevant to men's SCC risk. This may be attributable to different lifestyle between men and women.
人们普遍认为，在白种人群体中，阳光暴露是鳞状细胞癌（SCC）的一个风险因素。然而，在亚洲人群中，阳光暴露和阳光反应尚未得到探索，也没有针对特定性别的数据。
在一项病例对照研究中，我们于 1996 年至 1999 年从国立成功大学医学中心招募了 176 例新发皮肤癌病例。对照组包括来自台湾西南部的 216 名年龄、性别和居住相匹配的受试者。我们采用问卷调查收集了生活方式和其他风险因素的信息。我们采用 logistic 回归分析评估了阳光暴露或阳光反应与 SCC 风险之间的关联，并按性别进行了分层分析。
早发年龄（15 至 24 岁）和终生阳光暴露与 SCC 风险呈剂量反应关系，风险增加[比值比（OR）=1.49-3.08，趋势 p=0.009 和 0.0007]。按性别分层后，早发年龄阳光暴露的第三 tertile 与男性 SCC 风险显著相关（OR=3.08）。终生阳光暴露的第二 tertile 和第三 tertile 与女性 SCC 风险显著相关（OR=3.78 和 4.53）。儿童和青少年时期 2 小时阳光暴露后的皮肤反应与 SCC 风险无显著相关性。
终生阳光暴露与女性 SCC 风险的相关性更强，而早发年龄阳光暴露与男性 SCC 风险的相关性更强。这可能归因于男性和女性之间不同的生活方式。
