Pelucchi Claudio, Di Landro Anna, Naldi Luigi, La Vecchia Carlo
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
J Invest Dermatol. 2007 Apr;127(4):935-44. doi: 10.1038/sj.jid.5700598. Epub 2006 Oct 19.
Different clinico-pathologic subtypes and anatomic sites of basal-cell carcinoma (BCC) may display distinct characteristics and mechanisms of development. However, scanty information exists on potential differences in etiological factors for BCC according to histotype and anatomic location. Thus, we analyzed data from an Italian case-control study, including 528 subjects with newly diagnosed, histologically confirmed BCC and 512 controls admitted to the same hospitals with acute conditions. The multivariate odds ratio (OR) of nodular (OR=1.53) but not superficial (OR=0.71) BCC was increased for occupational exposure to sunlight. Considering the anatomic site of BCC, the corresponding values were 1.46 for head/neck and 0.74 for truncal location. Direct associations were observed with recreational sunlight exposure, eye color, red hair, and number and early age of severe sunburn episodes, along with some differences in risk between histotypes and anatomic sites. This study confirmed the role of (intermittent) sun exposure and phenotypic characteristics as risk factors for BCC, and suggested etiological differences between nodular and superficial histotypes and between head/neck and truncal locations.
基底细胞癌（BCC）的不同临床病理亚型和解剖部位可能表现出不同的特征和发展机制。然而，关于BCC病因因素根据组织学类型和解剖位置的潜在差异的信息却很少。因此，我们分析了一项意大利病例对照研究的数据，该研究包括528例新诊断、经组织学确诊的BCC患者和512例因急性病入住同一家医院的对照者。职业性阳光暴露使结节状BCC（比值比[OR]=1.53）而非浅表性BCC（OR=0.71）的多变量比值比升高。考虑到BCC的解剖部位，头颈部的相应值为1.46，躯干部位为0.74。观察到与娱乐性阳光暴露、眼睛颜色、红头发以及严重晒伤发作的次数和早期年龄直接相关，同时组织学类型和解剖部位之间在风险上也存在一些差异。这项研究证实了（间歇性）阳光暴露和表型特征作为BCC风险因素的作用，并提示结节状和浅表性组织学类型之间以及头颈部和躯干部位之间存在病因差异。
