Moghimi-Dehkordi B, Safaee A, Ghiasi S, Zali M R
Research Center for Gastroenterology and Liver Diseases, Shahid Beheshti University, M.C, Tehran, Iran.
East Afr J Public Health. 2009 Apr;6 Suppl(1):41-4. doi: 10.4314/eajph.v6i3.45773.
Cancer for a long time has been recognized as a fatal disease. Thus it is known to be major health problem in many countries throughout the world. In recent years, cancer morbidity and mortality increased in our country and especially gastric cancer has second order among all cancers. The aim of this study was to analysis the survival of patients diagnosed with gastric cancer and the factors which modify prognosis.
Retrospective study of overall patients diagnosed with gastric cancer registered in the cancer registry center of Research Center for Gastroenterology and Liver Disease (RCGLD), Shahid Beheshti University, M.C, Tehran, Iran, between Dec. 2001 and Dec. 2006 was done. Survival status of patients was followed by the telephone contact. The Kaplan-Meier statistical method was employed to determine the probability of survival and log-rank test to compare those. Cox regression was used to determine prognosis factors. P < 0.05 was considered as statistically significant. All calculations were carried out by SPSS (version13.0) statistical software.
Of 746 patients, 38.6% are dead. The mean and median survival time was 42.45 and 22.8 months, respectively and five-year survival rate was 25.3%. With univariate analysis, Age at Diagnosis, surgery treatment, type of first treatment, pathologic stage, tumor size, histology type of tumor, extent of wall penetration and pathologic distant metastasis were significant prognostic factors related to overall survival time. Tumor size greater than 35mm (HR = 2.12) and have a metastasis (HR = 2.04) were found to be the statistically significant poor prognostic factors related to survival in multivariate analysis.
According to results, early detection of cancer in lower ages and in primary grades of tumor is important to increase patient's life expectancy.
长期以来，癌症一直被视为一种致命疾病。因此，它是世界上许多国家的主要健康问题。近年来，我国癌症的发病率和死亡率有所上升，尤其是胃癌在所有癌症中位居第二。本研究的目的是分析胃癌患者的生存率以及影响预后的因素。
对2001年12月至2006年12月期间在伊朗德黑兰沙希德·贝赫什提大学医学中心胃肠病学和肝病研究中心癌症登记中心登记的所有胃癌患者进行回顾性研究。通过电话联系追踪患者的生存状况。采用Kaplan-Meier统计方法确定生存概率，并使用对数秩检验进行比较。采用Cox回归确定预后因素。P < 0.05被认为具有统计学意义。所有计算均通过SPSS（版本13.0）统计软件进行。
746例患者中，38.6%已死亡。平均生存时间和中位生存时间分别为42.45个月和22.8个月，五年生存率为25.3%。单因素分析显示，诊断年龄、手术治疗、首次治疗类型、病理分期、肿瘤大小、肿瘤组织学类型、壁层浸润范围和病理远处转移是与总生存时间相关的重要预后因素。多因素分析发现，肿瘤大小大于35mm（HR = 2.12）和有转移（HR = 2.04）是与生存相关的统计学显著不良预后因素。
根据结果，在较低年龄和肿瘤早期阶段早期发现癌症对于提高患者的预期寿命很重要。
