探讨肿瘤细胞代谢。
Chewing the fat on tumor cell metabolism.
机构信息
Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
出版信息
Cell. 2010 Jan 8;140(1):28-30. doi: 10.1016/j.cell.2009.12.037.
PMID:20085702
Abstract
Tumor cells undergo a metabolic shift toward specific bioenergetic (glycolysis) and anabolic (protein and lipid synthesis) processes that promote rapid growth. Nomura et al. (2010) now demonstrate that an increase in monoacylglycerol lipase (MAGL) drives tumorigenesis through the lipolytic release and remodeling of free fatty acids.
摘要
肿瘤细胞经历代谢转变，向特定的生物能量（糖酵解）和合成代谢（蛋白质和脂质合成）过程转变，从而促进快速生长。Nomura 等人（2010 年）现在证明，单酰基甘油脂肪酶（MAGL）的增加通过游离脂肪酸的脂解释放和重塑来驱动肿瘤发生。
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