微调沉默。
Fine-tuning silencing.
机构信息
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA.
出版信息
Cell Stem Cell. 2010 Jan 8;6(1):3-4. doi: 10.1016/j.stem.2009.12.013.
Abstract
Polycomb Repressive Complex 2 (PRC2) modifies chromatin to silence many embryonic patterning genes, restricting their expression to the appropriate cell populations. Two reports in Cell by Peng et al. (2009) and Shen et al. (2009) identify Jarid2/Jumonji, a new component of PRC2, which inhibits PRC2 enzymatic activity to fine-tune silencing.
摘要
多梳抑制复合物 2（PRC2）修饰染色质以沉默许多胚胎模式形成基因，将其表达限制在适当的细胞群体中。Peng 等人（2009 年）和 Shen 等人（2009 年）在《细胞》杂志上的两项报告确定了 Jarid2/Jumonji，这是 PRC2 的一个新成分，它抑制 PRC2 的酶活性以精细调节沉默。
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