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精神病学中的神经影像学:从实验室到临床

Neuroimaging in psychiatry: from bench to bedside.

作者信息

Linden David E J, Fallgatter Andreas J

机构信息

Bangor Imaging Unit, Wolfson Centre for Clinical and Cognitive Neuroscience, School of Psychology, Bangor University Bangor, UK.

出版信息

Front Hum Neurosci. 2009 Dec 23;3:49. doi: 10.3389/neuro.09.049.2009. eCollection 2009.

Abstract

This perspective considers the present and the future role of different neuroimaging techniques in the field of psychiatry. After identifying shortcomings of the mainly symptom-focussed diagnostic processes and treatment decisions in modern psychiatry, we suggest topics where neuroimaging methods have the potential to help. These include better understanding of the pathophysiology, improved diagnoses, assistance in therapeutic decisions and the supervision of treatment success by direct assessment of improvement in disease-related brain functions. These different questions are illustrated by examples from neuroimaging studies, with a focus on severe mental and neuropsychiatric illnesses such as schizophrenia and depression. Despite all reservations addressed in the article, we are optimistic that neuroimaging has a huge potential with regard to the above-mentioned questions. We expect that neuroimaging will play an increasing role in the future refinement of the diagnostic process and aid in the development of new therapies in the field of psychiatry.

摘要

这一观点探讨了不同神经影像学技术在精神病学领域当前及未来所发挥的作用。在明确现代精神病学中主要以症状为导向的诊断过程及治疗决策存在的缺陷后,我们提出了神经影像学方法有潜力提供帮助的主题。这些主题包括更好地理解病理生理学、改进诊断、辅助治疗决策以及通过直接评估与疾病相关的脑功能改善情况来监测治疗效果。通过神经影像学研究的实例对这些不同问题进行了说明,重点关注精神分裂症和抑郁症等严重精神及神经精神疾病。尽管本文中提出了所有保留意见,但我们仍乐观地认为,神经影像学在上述问题方面具有巨大潜力。我们预计,神经影像学在未来完善诊断过程以及助力精神病学领域新疗法的开发中将发挥越来越重要的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/39a2/2807751/e11d4383431c/fnhum-03-049-g001.jpg

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