一锅法中通过新的 Ugi 变体和 Pictet-Spengler 反应得到三轮车。
Tricycles by a new Ugi variation and Pictet-Spengler reaction in one pot.
机构信息
Department of Pharmaceutical Science, University of Pittsburgh, BST-3, 3501 Fifth Ave, Pittsburgh, PA, USA.
出版信息
Chemistry. 2013 Jun 17;19(25):8048-52. doi: 10.1002/chem.201300962. Epub 2013 May 6.
Abstract
Subsequent mild cyclization of aromatic substrates by Pictet-Spengler condensation stereoselectively gave new tricyclic compounds. Examples are described in decent yields over two steps in one pot, and a crystal structure is also presented to support the proposed structures.
摘要
通过Pictet-Spengler 缩合反应对芳香底物进行后续温和环化，可以立体选择性地得到新的三环化合物。在一锅两步反应中以相当高的收率得到了实例，并提供了一个晶体结构来支持所提出的结构。
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