Golestan Heart Research Center and Department of Cardiology, 5th Azar Hospital, Golestan University of Medical Sciences, 5th Azar Avenue, Gorgan, Iran.
Singapore Med J. 2009 Dec;50(12):1177-83.
It has been suggested that hypertension (HTN) is associated with certain target organ damage (TOD) and related clinical conditions. On the other hand, left ventricular hypertrophy (LVH) has been considered as an independent risk factor of cardiovascular events and death. The aim of this study was to examine the relationship between HTN-induced LVH and TOD (retinopathy and renal failure).
We assessed 102 hypertensive subjects (43 males and 59 females) with a mean age of 60.2 +/- 8.8 (range 35-81) years. LVH was defined as a left ventricular mass index (LVMI) of more than 51 and 47 g/(m [to the power of 2.7]), in men and women, respectively. The degree of retinopathy on ophthalmological examination was defined according to the Keith-Wagener classification. Serum creatinine, blood urea nitrogen and urine protein concentrations were also measured.
Hypertensive retinopathy was found in 94 (92.2 percent) cases (Grades I 55.9 percent; II 28.5 percent; III 3.9 percent; IV: 3.9 percent). The mean systolic and diastolic blood pressures and serum creatinine concentration showed significant correlation with the severity of LVH. There was no significant relationship between LVH severity and retinopathy or proteinuria.
The tight control of systolic and diastolic blood pressures in the first step of essential hypertension can assist to postpone LVH. Furthermore, routine measurement of serum creatinine can predict the risk of cardiovascular complications in the hypertensive patient.
有人认为高血压（HTN）与某些靶器官损伤（TOD）和相关临床情况有关。另一方面，左心室肥厚（LVH）已被认为是心血管事件和死亡的独立危险因素。本研究旨在探讨 HTN 引起的 LVH 与 TOD（视网膜病变和肾衰竭）之间的关系。
我们评估了 102 名高血压患者（43 名男性和 59 名女性），平均年龄为 60.2±8.8（范围 35-81）岁。LVH 的定义为左心室质量指数（LVMI）男性超过 51 和 47 g/（m [幂为 2.7]），女性分别为。眼科检查中视网膜病变的程度根据 Keith-Wagener 分类定义。还测量了血清肌酐、血尿素氮和尿蛋白浓度。
高血压视网膜病变在 94 例（92.2%）患者中发现（I 级 55.9%；II 级 28.5%；III 级 3.9%；IV 级：3.9%）。收缩压和舒张压以及血清肌酐浓度的平均值与 LVH 的严重程度呈显著相关。LVH 严重程度与视网膜病变或蛋白尿之间无显著关系。
原发性高血压第一步中收缩压和舒张压的严格控制有助于延缓 LVH。此外，血清肌酐的常规测量可以预测高血压患者心血管并发症的风险。
