Department of Biomedical Engineering and Physics, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Ann Biomed Eng. 2010 Mar;38(3):1216-24. doi: 10.1007/s10439-010-9903-y. Epub 2010 Jan 20.
Biofluid mechanics is increasingly applied in support of diagnosis and decision-making for treatment of clinical pathologies. Exploring the relationship between blood flow phenomena and pathophysiological observations is enhanced by continuing advances in the imaging modalities, measurement techniques, and capabilities of computational models. When combined with underlying physiological models, a powerful set of tools becomes available to address unmet clinical needs, predominantly in the direction of enhanced diagnosis, as well as assessment and prediction of treatment outcomes. This position paper presents an overview of current approaches and future developments along this theme that were discussed at the 5th International Biofluid Symposium and Workshop held at the California Institute of Technology in 2008. The introduction of novel mechanical biomarkers in device design and optimization, and applications in the characterization of more specific and focal conditions such as aneurysms, are at the center of attention. Further advances in integrative modeling, incorporating multiscale and multiphysics techniques are also discussed.
生物流体力学在支持临床病理学的诊断和决策制定方面的应用越来越广泛。通过不断推进成像方式、测量技术和计算模型的能力，血液流动现象与病理生理学观察之间的关系得到了加强。当与基础生理模型相结合时，就可以获得一组强大的工具，用于解决未满足的临床需求，主要是在增强诊断以及评估和预测治疗效果方面。本立场文件概述了 2008 年在加利福尼亚理工学院举行的第 5 届国际生物流体研讨会和专题讨论会上讨论的这一主题的当前方法和未来发展。在设备设计和优化中引入新型机械生物标志物，以及在更具体和集中的情况下（如动脉瘤）的特征描述中的应用，是关注的中心。还讨论了多尺度和多物理技术综合建模方面的进一步进展。
