来自[具体来源未给出]的超帕图洛内酯A - F，多环多异戊烯基化酰基间苯三酚及其细胞毒性活性。
Hyperpatulones A-F, polycyclic polyprenylated acylphloroglucinols from and their cytotoxic activities.
作者信息
Wu Zhong-Nan, Niu Qian-Wen, Zhang Yu-Bo, Luo Ding, Li Qing-Guo, Li Ying-Ying, Kuang Guang-Kai, He Li-Jun, Wang Guo-Cai, Li Yao-Lan
机构信息
Institute of Traditional Chinese Medicine & Natural Products, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University Guangzhou 510632 People's Republic of China
Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University Guangzhou 510632 People's Republic of China.
出版信息
RSC Adv. 2019 Mar 12;9(14):7961-7966. doi: 10.1039/c9ra00277d. eCollection 2019 Mar 6.
Six new compounds, hyperpatulones A-F (1-6), along with ten additional known related derivatives (7-16), were isolated from (Guttiferae). Their structures were elucidated by extensive analysis of spectroscopic data (IR, UV, HRESIMS, 1D and 2D NMR), X-ray crystallography, electronic circular dichroism (ECD) spectroscopy and Rh(OCOCF)-induced ECD. All compounds were tested for their cytotoxic activities on human HepG-2, HeLa, MCF-7, and A549 cell lines 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Compound 5 exhibited significant cytotoxicities against HepG-2, HeLa and A549 cell lines with IC values of 9.52 ± 0.27, 11.87 ± 0.22 and 12.63 ± 0.12 μM, respectively.
从藤黄科植物中分离得到了6个新化合物，即hyperpatulones A-F（1-6），以及另外10个已知的相关衍生物（7-16）。通过对光谱数据（红外光谱、紫外光谱、高分辨电喷雾电离质谱、一维和二维核磁共振谱）、X射线晶体学、电子圆二色光谱和铑（OCOCF）诱导的电子圆二色光谱进行广泛分析，阐明了它们的结构。采用3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐（MTT）法，对所有化合物针对人肝癌细胞系HepG-2、人宫颈癌细胞系HeLa、人乳腺癌细胞系MCF-7和人肺癌细胞系A549进行了细胞毒性活性测试。化合物5对HepG-2、HeLa和A549细胞系表现出显著的细胞毒性，其半数抑制浓度（IC）值分别为9.52±0.27、11.87±0.22和12.63±0.12 μM。
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