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1
Quinoline: A versatile heterocyclic.喹啉：一种多功能杂环化合物。
Saudi Pharm J. 2013 Jan;21(1):1-12. doi: 10.1016/j.jsps.2012.03.002. Epub 2012 Mar 29.
2
Recent Progress in the Synthesis of Quinolines.喹啉合成的最新进展
Curr Org Synth. 2019;16(5):671-708. doi: 10.2174/1570179416666190719112423.
3
Synthetic Strategies for Quinoline Based Derivatives as Potential Bioactive Heterocycles.基于喹啉的衍生物作为潜在的生物活性杂环的合成策略。
Curr Org Synth. 2023;20(6):606-629. doi: 10.2174/1570179420666221004143910.
4
A comprehensive review on the biological interest of quinoline and its derivatives.喹啉及其衍生物的生物学研究进展综述
Bioorg Med Chem. 2021 Feb 15;32:115973. doi: 10.1016/j.bmc.2020.115973. Epub 2020 Dec 31.
5
Recent Updates on Synthesis, Biological Activity, and Structure-activity Relationship of 1,3,4-Oxadiazole-quinoline Hybrids: A Review.1,3,4-恶二唑-喹啉杂化物的合成、生物活性及构效关系研究进展：综述
Curr Org Synth. 2023;20(7):758-787. doi: 10.2174/1570179420666221004142659.
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Quinoline as a Privileged Structure: A Recent Update on Synthesis and Biological Activities.喹啉作为一种优势结构：合成与生物活性的最新研究进展。
Curr Top Med Chem. 2024;24(27):2377-2419. doi: 10.2174/0115680266314303240830074056.
7
Friedlӓnder's synthesis of quinolines as a pivotal step in the development of bioactive heterocyclic derivatives in the current era of medicinal chemistry.弗里德兰德喹啉合成法是当代药物化学中生物活性杂环衍生物发展的关键步骤。
Chem Biol Drug Des. 2022 Dec;100(6):1042-1085. doi: 10.1111/cbdd.14044. Epub 2022 Apr 7.
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Quinoline-derivatives as privileged scaffolds for medicinal and pharmaceutical chemists: A comprehensive review.喹啉衍生物作为药物和制药化学家的优势骨架：全面综述。
Chem Biol Drug Des. 2022 Sep;100(3):389-418. doi: 10.1111/cbdd.14099. Epub 2022 Jun 16.
9
Recent Developments of Quinoline Derivatives and their Potential Biological Activities.喹啉衍生物的最新研究进展及其潜在的生物活性。
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Identification of quinoline-chalcones and heterocyclic chalcone-appended quinolines as broad-spectrum pharmacological agents.鉴定喹啉查耳酮和杂环查尔酮取代喹啉作为广谱药理试剂。
Bioorg Chem. 2020 Dec;105:104419. doi: 10.1016/j.bioorg.2020.104419. Epub 2020 Oct 22.

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Quinoline derivatives' biological interest for anti-malarial and anti-cancer activities: an overview.喹啉衍生物在抗疟疾和抗癌活性方面的生物学意义：综述。
RSC Adv. 2025 Aug 27;15(37):30576-30604. doi: 10.1039/d5ra00534e. eCollection 2025 Aug 22.
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Design strategies, structural insights, and biological potential of amyloid-beta inhibitors in Alzheimer's disease.阿尔茨海默病中β-淀粉样蛋白抑制剂的设计策略、结构见解及生物学潜力
Mol Divers. 2025 Jul 3. doi: 10.1007/s11030-025-11278-4.
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Assessment of the rat acute oral toxicity of quinoline-based pharmaceutical scaffold molecules using QSTR, q-RASTR and machine learning methods.使用定量结构-活性关系（QSTR）、定量响应-活性关系（q-RASTR）和机器学习方法评估喹啉类药物支架分子的大鼠急性经口毒性。
Mol Divers. 2025 Jun 27. doi: 10.1007/s11030-025-11265-9.
4
Cytotoxic, Genotoxic, Apoptotic, and Reactive Oxygen Generating Properties of Bioactive Quinoline Derivatives as Novel Anti Breast Cancer Agents.生物活性喹啉衍生物作为新型抗乳腺癌药物的细胞毒性、遗传毒性、凋亡诱导及活性氧生成特性
Cell Biochem Biophys. 2025 Jun 10. doi: 10.1007/s12013-025-01793-4.
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Molecular Hybrids of Quinoline and Sulfonamide: Design, Synthesis and in Vitro Anticancer Studies.喹啉与磺酰胺的分子杂化物：设计、合成及体外抗癌研究
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Synthesis of arylated tetrahydrobenzo[]quinoline-3-carbonitrile derivatives as potential hits for treatment of diabetes.芳基化四氢苯并[]喹啉-3-腈衍生物的合成作为治疗糖尿病的潜在活性化合物
Future Med Chem. 2024 Dec;16(24):2609-2625. doi: 10.1080/17568919.2024.2419359. Epub 2024 Nov 12.
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Quinoline Synthesis: Nanocatalyzed Green Protocols-An Overview.喹啉合成：纳米催化绿色方法概述
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Pd-, Cu-, and Ni-Catalyzed Reactions: A Comprehensive Review of the Efficient Approaches towards the Synthesis of Antibacterial Molecules.钯、铜和镍催化的反应：合成抗菌分子的有效方法综述
Pharmaceuticals (Basel). 2024 Oct 15;17(10):1370. doi: 10.3390/ph17101370.
9
Quinoline as a Privileged Structure: A Recent Update on Synthesis and Biological Activities.喹啉作为一种优势结构：合成与生物活性的最新研究进展。
Curr Top Med Chem. 2024;24(27):2377-2419. doi: 10.2174/0115680266314303240830074056.
10
Antioxidant Activities of Exopolysaccharides Extracts from Two Endemic Fungi from Patagonia.来自巴塔哥尼亚两种特有真菌的胞外多糖提取物的抗氧化活性。
Curr Microbiol. 2024 Sep 17;81(11):361. doi: 10.1007/s00284-024-03883-7.

本文引用的文献

1
Synthesis and c-Met kinase inhibition of 3,5-disubstituted and 3,5,7-trisubstituted quinolines: identification of 3-(4-acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a novel anticancer agent.3,5-二取代和 3,5,7-三取代喹啉的合成及 c-Met 激酶抑制作用：鉴定出 3-(4-乙酰哌嗪-1-基)-5-(3-硝基苄氨基)-7-(三氟甲基)喹啉为新型抗癌剂。
J Med Chem. 2011 Apr 14;54(7):2127-42. doi: 10.1021/jm101340q. Epub 2011 Mar 15.
2
Design, synthesis, and evaluation of novel 3,6-diaryl-4-aminoalkoxyquinolines as selective agonists of somatostatin receptor subtype 2.设计、合成及评估新型 3,6-二芳基-4-氨基烷氧基喹啉类作为生长抑素受体亚型 2 的选择性激动剂。
J Med Chem. 2011 Apr 14;54(7):2351-8. doi: 10.1021/jm101501b. Epub 2011 Mar 11.
3
Antimalarial activity of novel 5-aryl-8-aminoquinoline derivatives.新型 5-芳基-8-氨基喹啉衍生物的抗疟活性。
J Med Chem. 2011 Jan 13;54(1):131-42. doi: 10.1021/jm100911f. Epub 2010 Dec 8.
4
Synthesis of 2-alkoxy(aroxy)-3-substituted quinolines by DABCO-promoted cyclization of o-alkynylaryl isocyanides.通过 DABCO 促进的邻炔基芳基异氰化物环化反应合成 2-烷氧基（芳氧基）-3-取代喹啉。
J Org Chem. 2010 Nov 5;75(21):7502-4. doi: 10.1021/jo1017525.
5
Ultrasound promoted synthesis of quinolines using basic ionic liquids in aqueous media as a green procedure.超声促进喹啉的合成，在水相介质中使用碱性离子液体作为绿色方法。
Ultrason Sonochem. 2011 Jan;18(1):447-54. doi: 10.1016/j.ultsonch.2010.07.020. Epub 2010 Aug 6.
6
Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.新型他克林-8-羟基喹啉杂合体作为治疗阿尔茨海默病的多效药物，具有神经保护、胆碱能、抗氧化和铜络合性质。
J Med Chem. 2010 Jul 8;53(13):4927-37. doi: 10.1021/jm100329q.
7
New quinoline derivatives: synthesis and investigation of antibacterial and antituberculosis properties.新型喹啉衍生物的合成及抗菌、抗结核活性研究。
Eur J Med Chem. 2010 Aug;45(8):3374-83. doi: 10.1016/j.ejmech.2010.04.022. Epub 2010 Apr 28.
8
A method for the synthesis of substituted quinolines via electrophilic cyclization of 1-azido-2-(2-propynyl)benzene.一种通过 1-叠氮-2-(2-丙炔基)苯的亲电环化合成取代喹啉的方法。
J Org Chem. 2010 Feb 19;75(4):1266-70. doi: 10.1021/jo902603v.
9
Unexpected domino reaction via Pd-catalyzed Sonogashira coupling of benzimidoyl chlorides with 1,6-enynes and cyclization to synthesize quinoline derivatives.钯催化苯并咪唑氯与 1,6-烯炔的 Sonogashira 偶联反应及环化合成喹啉衍生物的意外级联反应。
J Org Chem. 2010 Feb 19;75(4):1305-8. doi: 10.1021/jo9026116.
10
Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform.利用1,2,3,4-四氢喹啉平台设计与合成胆固醇酯转移蛋白（CETP）的强效抑制剂。
Bioorg Med Chem Lett. 2009 May 1;19(9):2456-60. doi: 10.1016/j.bmcl.2009.03.051. Epub 2009 Mar 18.

喹啉：一种多功能杂环化合物。

Quinoline: A versatile heterocyclic.

机构信息

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi 110 062, India.

出版信息

Saudi Pharm J. 2013 Jan;21(1):1-12. doi: 10.1016/j.jsps.2012.03.002. Epub 2012 Mar 29.

DOI:10.1016/j.jsps.2012.03.002
PMID:23960814
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3744984/
Abstract

Quinoline or 1-aza-naphthalene is a weak tertiary base. Quinoline ring has been found to possess antimalarial, anti-bacterial, antifungal, anthelmintic, cardiotonic, anticonvulsant, anti-inflammatory, and analgesic activity. Quinoline not only has a wide range of biological and pharmacological activities but there are several established protocols for the synthesis of this ring. The article aims at highlighting these very diversities of the ring.

摘要

喹啉或 1-氮萘是一种弱的叔胺。已发现喹啉环具有抗疟、抗菌、抗真菌、驱虫、强心、抗惊厥、抗炎和镇痛活性。喹啉不仅具有广泛的生物和药理活性，而且有几种已建立的合成该环的方法。本文旨在强调该环的这些多样性。