Kee M-K, Lee J-H, Kim G J, Choi B-S, Hong K-J, Lee J-S, Kim S S
Division of AIDS, Center for Immunology and Pathology, Korea National Institute of Health, Seoul, Korea.
Int J STD AIDS. 2010 Feb;21(2):120-5. doi: 10.1258/ijsa.2008.008405.
The aim of the study was to evaluate the trends of initial CD4+ T-cell counts (CD4+) at HIV diagnoses and to identify the factors influencing the annual changes of CD4+ cell counts in Korea during 1988-2006. As a retrospective study, 2613 individuals (>/=15 years at diagnosis, their CD4+ counts were measured within six months) were selected from all 4580 HIV-infected Koreans diagnosed between 1985 and 2006. The mean CD4+ cell counts in all the selected individuals was 312 cells/mm(3), and this value decreased significantly by 20.3 cells/mm(3)/year over the 19 year study period. Men had lower CD4+ cell count than women by 22.7 cells/mm(3), and age at HIV diagnosis had an inverse relationship with CD4+ cell counts of 23.5 cells/mm(3) lower per 10 years advancing age. Cases diagnosed in hospitals showed CD4+ cell count levels 33.9 cells/mm(3) lower than public institutions by 33.9 cells/mm(3). Gender and age seemed to affect trends of CD4+ count; however the institution where cases were diagnosed had the strongest effect on decreasing CD4+ cell counts. The results suggest that HIV diagnoses in recent years are being made in later stages of HIV infection and that it is imperative to develop more efficient programmes for early HIV diagnosis to prevent transmission.
该研究的目的是评估韩国1988 - 2006年期间HIV诊断时初始CD4 + T细胞计数（CD4 +）的变化趋势，并确定影响CD4 +细胞计数年度变化的因素。作为一项回顾性研究，从1985年至2006年诊断出的4580名韩国HIV感染者中选取了2613名个体（诊断时年龄≥15岁，其CD4 +计数在6个月内测量）。所有选定个体的平均CD4 +细胞计数为312个细胞/mm³，在19年的研究期间，该值以每年20.3个细胞/mm³的速度显著下降。男性的CD4 +细胞计数比女性低22.7个细胞/mm³，HIV诊断时的年龄与CD4 +细胞计数呈负相关，每增长10岁，CD4 +细胞计数降低23.5个细胞/mm³。在医院诊断的病例显示CD4 +细胞计数水平比公共机构低33.9个细胞/mm³。性别和年龄似乎影响CD4 +计数的趋势；然而，病例诊断所在的机构对CD4 +细胞计数下降的影响最大。结果表明，近年来HIV诊断是在HIV感染的后期进行的，因此必须制定更有效的早期HIV诊断计划以预防传播。
