Department of Infectious Disease, Inha University Hospital, Incheon, Korea.
J Korean Med Sci. 2012 Aug;27(8):969-71. doi: 10.3346/jkms.2012.27.8.969. Epub 2012 Jul 25.
The number of HIV-infected individuals susceptible to Hepatitis A virus (HAV) infection is increasing in Korea; however, it has proven difficult to devise a vaccination policy therefore because limited seroepidemiologic data exists for them. Accordingly, anti-HAV IgG was measured in 188 HIV-infected adults between July 2008 and July 2010. The nadir CD4+ T lymphocyte counts were not different between the HAV-positive and -negative groups (197 ± 138 vs 202 ± 129, P = 0.821). The only factor independently associated with seropositive status was age under 40 yr old (OR 0.017, P < 0.001). Our findings suggest that HAV vaccination in HIV-infected adults should be targeted at persons under the age of 40 yr.
在韩国，感染 HIV 的个体易感染甲型肝炎病毒 (HAV) 的人数正在增加；然而，由于针对他们的血清流行病学数据有限，因此很难制定疫苗接种政策。因此，我们在 2008 年 7 月至 2010 年 7 月期间对 188 名 HIV 感染的成年人测量了抗-HAV IgG。HAV 阳性组和阴性组的 CD4+T 淋巴细胞计数最低值没有差异（197 ± 138 与 202 ± 129，P = 0.821）。唯一与血清阳性状态独立相关的因素是年龄小于 40 岁（OR 0.017，P < 0.001）。我们的研究结果表明，应针对年龄小于 40 岁的 HIV 感染成年人进行 HAV 疫苗接种。
