Crowe R R, Black D W, Wesner R, Andreasen N C, Cookman A, Roby J
Department of Psychiatry, University of Iowa College of Medicine, Iowa City 52242.
Arch Gen Psychiatry. 1991 Apr;48(4):357-61. doi: 10.1001/archpsyc.1991.01810280073010.
We examined linkage between schizophrenia and five genetic markers on chromosome 5 in six pedigrees. Analyses were run considering the affected phenotype to be schizophrenia, schizophrenia plus a spectrum of related disorders, and these disorders plus any axis I diagnosis. None of the analyses were suggestive of linkage at any of the markers, either considering the pedigrees individually or in the aggregate. In our pedigrees, multipoint linkage analyses excluded much of the region that had supported linkage in an earlier study. These findings are consistent with other attempts to replicate the chromosome 5 linkage finding.
我们在六个家系中研究了精神分裂症与5号染色体上五个遗传标记之间的连锁关系。分析时考虑的受影响表型分别为精神分裂症、精神分裂症加上一系列相关障碍，以及这些障碍再加上任何轴I诊断。无论是单独考虑各个家系还是将家系汇总分析，所有分析均未显示任何标记存在连锁关系。在我们的家系中，多点连锁分析排除了早期一项研究中支持连锁关系的大部分区域。这些发现与其他复制5号染色体连锁发现的尝试结果一致。
