Detera-Wadleigh S D, Goldin L R, Sherrington R, Encio I, de Miguel C, Berrettini W, Gurling H, Gershon E S
Clinical Neurogenetics Branch, National Institute of Mental Health, Bethesda, Maryland 20892.
Nature. 1989 Aug 3;340(6232):391-3. doi: 10.1038/340391a0.
Recently a linkage study on five Icelandic and two English pedigrees has provided evidence for a dominant gene for schizophrenia on 5q11-13 (ref. 1). In that study, families with bipolar illness were not included. Using the same probes, two similar but independent investigations on one Swedish pedigree and on fifteen Scottish families excluded linkage to schizophrenia. To evaluate whether the susceptibility gene on 5q11-13 is a common cause of schizophrenia in other populations, we examined five affected North American pedigrees using probes to the D5S39, D5S76 and dihydrofolate reductase loci. Two families in the present series had cases of bipolar disorder. We found that linkage can be excluded by multipoint analysis. These results, taken together, suggest that the disease gene on 5q11-13 does not account for most cases of familial schizophrenia.
最近，一项针对五个冰岛家系和两个英国家系的连锁研究为位于5q11 - 13的精神分裂症显性基因提供了证据（参考文献1）。在该研究中，未纳入双相情感障碍家系。使用相同的探针，对一个瑞典家系和十五个苏格兰家系进行了两项相似但独立的研究，排除了与精神分裂症的连锁关系。为评估位于5q11 - 13的易感基因是否是其他人群中精神分裂症的常见病因，我们使用针对D5S39、D5S76和二氢叶酸还原酶基因座的探针，对五个患病的北美家系进行了检测。本系列中的两个家系存在双相情感障碍病例。我们发现，通过多点分析可以排除连锁关系。综合这些结果表明，位于5q11 - 13的疾病基因并不能解释大多数家族性精神分裂症病例。
