排除5号染色体q11-q13区域的精神分裂症易感基因：新数据及对既往报告的重新分析
Exclusion of a schizophrenia susceptibility gene from the chromosome 5q11-q13 region: new data and a reanalysis of previous reports.
作者信息
McGuffin P, Sargeant M, Hetti G, Tidmarsh S, Whatley S, Marchbanks R M
机构信息
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff.
出版信息
Am J Hum Genet. 1990 Sep;47(3):524-35.
Abstract
The report of a putative schizophrenia susceptibility gene linked to markers in the chromosome 5q11-q13 region and subsequent failures of replication have provoked considerable controversy. We here report six Welsh families multiply affected with schizophrenia in which there is no evidence for linkage between a dominant-like schizophrenia gene and 5q11-q13 markers. It is argued that our new results together with a combined reanalysis of previous studies suggest that a schizophrenia susceptibility gene can be excluded from the 5q11-q13 region. The apparent disparities between published results are most likely to reflect a chance finding in the one positive study and probably should not be interpreted as resulting from true linkage heterogeneity.
摘要
一份关于假定的精神分裂症易感基因与5号染色体q11 - q13区域标记相关的报告，以及随后复制失败的情况引发了相当大的争议。我们在此报告六个精神分裂症多发的威尔士家族，其中没有证据表明类似显性的精神分裂症基因与5q11 - q13标记之间存在连锁关系。有人认为，我们的新结果以及对先前研究的综合重新分析表明，可以排除5q11 - q13区域存在精神分裂症易感基因。已发表结果之间明显的差异很可能反映了一项阳性研究中的偶然发现，或许不应被解释为真正的连锁异质性所致。
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