心肌损伤的分子成像：一种磁荧光方法。
Molecular Imaging of Myocardial Injury: A Magnetofluorescent Approach.
作者信息
Sosnovik David E
机构信息
Center for Molecular Imaging Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
出版信息
Curr Cardiovasc Imaging Rep. 2009 Feb 1;2(1):33-39. doi: 10.1007/s12410-009-0005-x.
Abstract
The role of molecular imaging in enhancing the understanding of myocardial injury and repair is rapidly expanding. Moreover, in recent years magnetic resonance and fluorescence-based approaches have been added to the molecular imaging armamentarium and have been used to image selected molecular and cellular targets in the myocardium. Apoptosis, necrosis, macrophage infiltration, myeloperoxidase activity, cathepsin activity, and type 1 collagen have all been imaged in vivo with a magnetofluorescent (MRI and/or fluorescence) approach. This review highlights the potential of these and other magnetofluorescent agents, with particular focus on their role in ischemic heart disease.
摘要
分子成像在加深对心肌损伤与修复的理解方面所起的作用正在迅速扩大。此外，近年来，磁共振和基于荧光的方法已被纳入分子成像手段，并已用于对心肌中选定的分子和细胞靶点进行成像。细胞凋亡、坏死、巨噬细胞浸润、髓过氧化物酶活性、组织蛋白酶活性和I型胶原都已通过磁荧光（MRI和/或荧光）方法在体内成像。本综述重点介绍了这些及其他磁荧光剂的潜力，特别关注它们在缺血性心脏病中的作用。
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