Duesberg P H, Bister K, Vogt P K
Proc Natl Acad Sci U S A. 1977 Oct;74(10):4320-4. doi: 10.1073/pnas.74.10.4320.
The RNA of myelocytoma virus MC29, a replication-defective avian acute leukemia virus, was investigated. Sedimentation and electrophoretic analyses indicated that the virus contains a distinct 28S RNA with about 5700 nucleotides. It is the smallest avian tumor virus RNA detected to date. The small size of the RNA suggests that the defectiveness of the virus is due to deletions in replicative genes. The RNA shared 3 to 5 of 30 large RNase T1-resistant oligonucleotides with the RNA of other avian leukosis and sarcoma and may represent the transforming information of the virus. Sequences of the conserved transforming gene of avian sarcoma viruses were not detected in MC29 RNA. It was concluded that the transforming sequences of MC29 RNA define a new class of avian tumor viral transforming genes.
对复制缺陷型禽急性白血病病毒——骨髓细胞瘤病毒MC29的RNA进行了研究。沉降和电泳分析表明，该病毒含有一种独特的28S RNA，约有5700个核苷酸。它是迄今为止检测到的最小的禽肿瘤病毒RNA。RNA的小尺寸表明该病毒的缺陷是由于复制基因中的缺失所致。该RNA与其他禽白血病和肉瘤的RNA共有30个对核糖核酸酶T1抗性的大寡核苷酸中的3至5个，可能代表了该病毒的转化信息。在MC29 RNA中未检测到禽肉瘤病毒保守转化基因的序列。得出的结论是，MC29 RNA的转化序列定义了一类新的禽肿瘤病毒转化基因。
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