Harvard School of Public Health, Boston, MA 02215, USA.
Am J Epidemiol. 2010 Feb 15;171(4):391-8. doi: 10.1093/aje/kwp416. Epub 2010 Jan 21.
Neighborhood socioeconomic environment may be a determinant of injection drug use cessation. The authors used data from a prospective cohort study of Baltimore City, Maryland, injection drug users assessed between 1990 and 2006. The study examined the relation between living in a poorer neighborhood and the probability of injection cessation among active injectors, independent of individual characteristics and while respecting the temporality of potential confounders, exposure, and outcome. Participants' residences were geocoded, and the crude, adjusted, and inverse probability of exposure weighted associations between neighborhood poverty and injection drug use cessation were estimated. Weighted models showed a strong association between neighborhood poverty and injection drug use cessation; living in a neighborhood with fewer than 10%, compared with more than 30%, of residents in poverty was associated with a 44% increased odds of not injecting in the prior 6 months (odds ratio = 1.44, 95% confidence interval: 1.14, 1.82). Results show that neighborhood environment may be an important determinant of drug injection behavior independent of individual-level characteristics.
社区社会经济环境可能是决定是否停止注射吸毒的一个因素。作者利用马里兰州巴尔的摩市前瞻性队列研究的数据，对 1990 年至 2006 年间的注射吸毒者进行了评估。该研究考察了生活在贫困社区与活跃注射者停止注射的概率之间的关系，这一关系独立于个人特征，同时尊重潜在混杂因素、暴露和结果的时间性。参与者的住所被进行了地理编码，对贫困社区与停止注射吸毒之间的粗关联、调整关联和暴露反概率加权关联进行了估计。加权模型显示，贫困社区与停止注射吸毒之间存在很强的关联；与生活在贫困居民比例超过 30%的社区相比，生活在贫困居民比例低于 10%的社区中，在过去 6 个月不注射毒品的可能性增加了 44%（比值比=1.44，95%置信区间：1.14，1.82）。结果表明，社区环境可能是独立于个人特征的药物注射行为的一个重要决定因素。
