Okkema A Z, Yu X H, Cooper S L
Materials Science Program, University of Wisconsin, Madison 53706.
Biomaterials. 1991 Jan;12(1):3-12. doi: 10.1016/0142-9612(91)90123-r.
Propyl sulphonate groups were grafted on to the backbone of Biomer, a polyetherurethaneurea, in an attempt to improve its blood-contacting properties. The bulk, surface and blood-contacting properties of this series of sulphonated polymers were evaluated. Differential scanning calorimetry and dynamic mechanical analysis indicated that propyl sulphonate incorporation increased the microphase separation of the polymers. The ultimate tensile strength was also increased with sulphonation at the expense of the polymer's extensibility. Dynamic contact angle analysis showed that, in water, the sulphonated Biomer surfaces were more polar than the Biomer sample indicating the propyl sulphonate groups were enriched at the surface. Canine ex vivo blood-contacting results showed that the incorporation of propyl sulphonate groups dramatically reduced the number and activation of platelets adherent to the polymer surface. In addition, fibrinogen deposition increased with increasing sulphonate content, despite the low level of platelet activation.
为了改善其血液接触性能，将丙基磺酸酯基团接枝到聚醚聚氨酯脲Biomer的主链上。对该系列磺化聚合物的体积、表面和血液接触性能进行了评估。差示扫描量热法和动态力学分析表明，丙基磺酸酯的引入增加了聚合物的微相分离。磺化处理后，极限拉伸强度也有所提高，但聚合物的延展性有所牺牲。动态接触角分析表明，在水中，磺化Biomer表面比Biomer样品更具极性，这表明丙基磺酸酯基团在表面富集。犬离体血液接触结果表明，丙基磺酸酯基团的引入显著减少了粘附在聚合物表面的血小板数量和活化程度。此外，尽管血小板活化水平较低，但纤维蛋白原沉积随着磺酸盐含量的增加而增加。
