Offit K, Wong G, Filippa D A, Tao Y, Chaganti R S
Laboratory of Cancer Genetics, Sloan-Kettering Institute, New York, NY.
Blood. 1991 Apr 1;77(7):1508-15.
Cytogenetic and histopathologic data were correlated with clinical parameters from 423 patients with non-Hodgkin's lymphoma (NHL). Clinical correlations were performed on subgroups of 149 patients with low-grade lymphoma (LG) and 205 patients with diffuse lymphoma with a large cell component (DLLC). Correlations were made between clinical outcome and individual recurring cytogenetic aberrations, each of which was noted in greater than 5% of cases belonging to LG NHL and DLLC, and derived measures of karyotypic complexity, comprising modal chromosome number, number of marker chromosomes, and number of translocation breakpoints. No correlations with survival were noted in LG NHL, although median follow-up was only 2 years. Seven patients with t(8;14) LG NHL had an indolent course. Among 104 patients with DLLC and abnormal karyotypes at diagnosis, breaks at 1q21-23 or more than 4 marker chromosomes was associated with a shortened median survival. Using these variables we constructed a proportional hazards model with a good fit to observed data. Breaks at 6q21-25 predicted a decreased probability of achieving remission. Patients with DLLC and breaks at 1q21-23 or 1p32-36 had a shorter duration of complete remission. Of 41 DLLC studied at relapse, the only long-term survivors had t(14;18).
细胞遗传学和组织病理学数据与423例非霍奇金淋巴瘤（NHL）患者的临床参数相关。对149例低度淋巴瘤（LG）患者和205例伴有大细胞成分的弥漫性淋巴瘤（DLLC）患者亚组进行了临床相关性分析。对临床结局与个体复发性细胞遗传学异常进行了相关性分析，每种异常在属于LG NHL和DLLC的病例中出现率均超过5%，并分析了核型复杂性的衍生指标，包括众数染色体数、标记染色体数和易位断点数量。在LG NHL中未发现与生存相关的情况，尽管中位随访时间仅为2年。7例t(8;14) LG NHL患者病程呈惰性。在104例诊断时核型异常的DLLC患者中，1q21 - 23处断裂或超过4条标记染色体与中位生存期缩短相关。利用这些变量构建了一个与观察数据拟合良好的比例风险模型。6q21 - 25处断裂预示缓解概率降低。DLLC且1q21 - 23或1p32 - 36处断裂的患者完全缓解持续时间较短。在复发时研究的41例DLLC患者中，唯一的长期幸存者具有t(14;18)。
