Offit K, Chaganti R S
Memorial Hospital, New York, New York.
Hematol Oncol Clin North Am. 1991 Oct;5(5):853-69.
Molecular characterization of chromosomal aberrations in non-Hodgkin's lymphoma (NHL) has provided a basic understanding of mechanisms of oncogene deregulation. Cytogenetic aberrations have been correlated with histologic subtype, immunophenotype, and clinical features of NHL. Although the incomplete specificity of some of the observed associations may limit the routine use of these markers in a clinical setting, the utilization of cytogenetic analysis can contribute to the diagnosis and management of patients with NHL.
非霍奇金淋巴瘤（NHL）染色体畸变的分子特征已为癌基因失调机制提供了基本认识。细胞遗传学畸变与NHL的组织学亚型、免疫表型及临床特征相关。尽管一些观察到的关联存在不完全特异性，可能会限制这些标志物在临床环境中的常规应用，但细胞遗传学分析的运用有助于NHL患者的诊断与管理。
