Dutton Richard P, Stansbury Lynn G, Leone Susan, Kramer Elizabeth, Hess John R, Scalea Thomas M
Program in Trauma, University of Maryland School of Medicine, Baltimore, Maryland, USA.
J Trauma. 2010 Sep;69(3):620-6. doi: 10.1097/TA.0b013e3181bbfe2a.
Advances in care such as damage control surgery, hemostatic resuscitation, protocol-driven cerebral perfusion management, and lung-protective ventilation have promised to improve survival after major trauma. We examined injury severity, mortality, and preventability in a mature trauma system during a 12-year period to assess the overall benefits of these and other improvements.
Using the institutional trauma registry and the quality management database, we analyzed the outcome and the cause of death for all primary trauma admissions from July 1, 1996, to June 30, 2008, and linked these data with patient demographics, hospital length of stay, time to death, predicted probability of survival, and peer review of in-hospital deaths.
Through fiscal year (FY) 2007, primary trauma admissions increased in number, injury severity, and age. Performance benchmarked against predicted probability of survival improved. Mortality through this era ranged from 3% to 3.7% and worsened slightly overall (p = 0.04). However, among those patients admitted with Injury Severity Score 17-25, survival improved significantly (p = 0.0003). Traumatic brain injury (TBI) accounted for 51.6% of deaths; acute hemorrhage, 30%; and multiple organ failure, 10.5%. Median time to death for uncontrollable hemorrhage, TBI, multiple organ failure was 2 hours, 24 hours, and 15 days, respectively. These patterns did not change significantly over time.
Survival after severe trauma and survival benchmarked against predicted risk improved significantly at our center during the past 12 years despite generally increasing age and worsening injuries. Advances in trauma care have kept pace with an aging population and greater severity of injury, but overall survival has not improved.
诸如损伤控制手术、止血复苏、基于方案的脑灌注管理以及肺保护性通气等治疗进展有望提高严重创伤后的生存率。我们在一个成熟的创伤系统中对12年间的损伤严重程度、死亡率及可预防性进行了研究,以评估这些及其他改善措施的总体效益。
利用机构创伤登记册和质量管理数据库,我们分析了1996年7月1日至2008年6月30日期间所有原发性创伤入院患者的结局和死亡原因,并将这些数据与患者人口统计学信息、住院时间、死亡时间、预测生存概率以及住院死亡病例的同行评审结果相联系。
截至2007财年,原发性创伤入院患者的数量、损伤严重程度和年龄均有所增加。与预测生存概率相比,治疗效果有所改善。这一时期的死亡率在3%至3.7%之间,总体略有上升(p = 0.04)。然而,在损伤严重程度评分为17 - 25分的患者中,生存率显著提高(p = 0.0003)。创伤性脑损伤(TBI)占死亡病例的51.6%;急性出血占30%;多器官功能衰竭占10.5%。无法控制的出血、TBI、多器官功能衰竭的中位死亡时间分别为2小时、24小时和15天。这些模式随时间未发生显著变化。
在过去12年中,尽管患者年龄普遍增加且损伤情况恶化,但我们中心严重创伤后的生存率以及与预测风险相比的生存基准显著提高。创伤治疗的进展已跟上人口老龄化和损伤严重程度增加的步伐,但总体生存率并未提高。