• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

猴病毒40 16S和19S mRNA 5'端的序列排列

Sequence arrangement of the 5' ends of simian virus 40 16S and 19S mRNAs.

作者信息

Hsu M T, Ford J

出版信息

Proc Natl Acad Sci U S A. 1977 Nov;74(11):4982-5. doi: 10.1073/pnas.74.11.4982.

DOI:10.1073/pnas.74.11.4982
PMID:200942
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC432082/
Abstract

Electron microscopic examination of molecular hybrids between simian virus 40 DNA, that had been cleaved with EcoRI and then digested with exonuclease III, and either 16S or 19S mRNA produced late during the viral infection cycle indicated that each of these mRNAs contained a 5'-terminal "leader" sequence that was encoded in the viral genome at about map position 0.71-0.75. Hybridization of each of these mRNAs to viral DNA immobilized on nitrocellulose filters supported the electron microscopic observations.

摘要

用EcoRI切割后再用核酸外切酶III消化的猴病毒40 DNA与在病毒感染周期后期产生的16S或19S mRNA之间的分子杂交体的电子显微镜检查表明，这些mRNA中的每一个都含有一个5'-末端“前导”序列，该序列在病毒基因组中大约位于图谱位置0.71 - 0.75处编码。这些mRNA与固定在硝酸纤维素滤膜上的病毒DNA的杂交支持了电子显微镜观察结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/432082/f80c067e9ed5/pnas00033-0284-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/432082/d047f473f00b/pnas00033-0282-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/432082/5fa83cd5d6ff/pnas00033-0283-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/432082/f80c067e9ed5/pnas00033-0284-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/432082/d047f473f00b/pnas00033-0282-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/432082/5fa83cd5d6ff/pnas00033-0283-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d304/432082/f80c067e9ed5/pnas00033-0284-a.jpg

相似文献

1
Sequence arrangement of the 5' ends of simian virus 40 16S and 19S mRNAs.猴病毒40 16S和19S mRNA 5'端的序列排列
Proc Natl Acad Sci U S A. 1977 Nov;74(11):4982-5. doi: 10.1073/pnas.74.11.4982.
2
5'-Terminal sequences and coding region of late simian virus 40 mRNAs are derived from noncontiguous segments of the viral genome.猴病毒40晚期mRNA的5'末端序列和编码区源自病毒基因组的非连续片段。
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5323-7. doi: 10.1073/pnas.74.12.5323.
3
Mapping of transcription sites of simian virus 40-specific late 16S and 19S mRNA by electron microscopy.通过电子显微镜对猴病毒40特异性晚期16S和19S mRNA转录位点的定位
Proc Natl Acad Sci U S A. 1977 Feb;74(2):496-500. doi: 10.1073/pnas.74.2.496.
4
Electron microscopic evidence for splicing of SV40 late mRNAs.SV40晚期mRNA剪接的电子显微镜证据。
Cell. 1978 Apr;13(4):783-90. doi: 10.1016/0092-8674(78)90228-3.
5
Mapping the spliced and unspliced late lytic SV40 RNAs.绘制剪接和未剪接的晚期裂解性SV40 RNA图谱。
Cell. 1978 Aug;14(4):971-82. doi: 10.1016/0092-8674(78)90351-3.
6
Mutational alterations within the simian virus 40 leader segment generate altered 16S and 19S mRNA's.猿猴病毒40前导序列内的突变改变产生了改变的16S和19S信使核糖核酸。
J Virol. 1979 Jan;29(1):209-19. doi: 10.1128/JVI.29.1.209-219.1979.
7
Capping structures of simian virus 40 19S and 16S mRNAs.猴病毒40 19S和16S mRNA的帽状结构
Nucleic Acids Res. 1977 Nov;4(11):3959-68. doi: 10.1093/nar/4.11.3959.
8
Isolation and characterization of simian virus 40 ribonucleic acid.猿猴病毒40核糖核酸的分离与特性鉴定
J Virol. 1972 Aug;10(2):193-201. doi: 10.1128/JVI.10.2.193-201.1972.
9
Mapping of sequences with 2-fold symmetry on the simian virus 40 genome: a photochemical crosslinking approach.猿猴病毒40基因组上具有二重对称性序列的图谱绘制：一种光化学交联方法。
Proc Natl Acad Sci U S A. 1977 Apr;74(4):1363-7. doi: 10.1073/pnas.74.4.1363.
10
Identification and mapping of N6-methyladenosine containing sequences in simian virus 40 RNA.猿猴病毒40 RNA中含N6-甲基腺苷序列的鉴定与定位
Nucleic Acids Res. 1979 Jun 25;6(8):2879-99. doi: 10.1093/nar/6.8.2879.

引用本文的文献

1
Simian virus 40-rabbit beta-globin recombinants lacking late mRNA splice sites express cytoplasmic RNAs with altered structures.缺乏晚期mRNA剪接位点的猿猴病毒40-兔β-珠蛋白重组体表达结构改变的细胞质RNA。
J Virol. 1982 Apr;42(1):262-74. doi: 10.1128/JVI.42.1.262-274.1982.
2
DNA sequence analysis of simian virus 40 mutants with deletions mapping in the leader region of the late viral mRNA's: mutants with deletions similar in size and position exhibit varied phenotypes.猿猴病毒40（Simian virus 40）突变体的DNA序列分析，这些突变体在病毒晚期mRNA前导区存在缺失：大小和位置相似的缺失突变体表现出不同的表型。
J Virol. 1981 Feb;37(2):730-7. doi: 10.1128/JVI.37.2.730-737.1981.
3

本文引用的文献

1
ENZYMIC SYNTHESIS OF DEOXYRIBONUCLEIC ACID. 18. THE REPAIR OF PARTIALLY SINGLE-STRANDED DNA TEMPLATES BY DNA POLYMERASE.脱氧核糖核酸的酶促合成。18. 用DNA聚合酶修复部分单链DNA模板
J Mol Biol. 1964 Jul;9:46-69. doi: 10.1016/s0022-2836(64)80090-5.
2
Fractionation of heterogeneous nuclear RNA: rates of hybridization and chromosomal distribution of reiterated sequences.不均一核RNA的分级分离：重复序列的杂交速率和染色体分布
J Mol Biol. 1970 Dec 28;54(3):517-35. doi: 10.1016/0022-2836(70)90123-3.
3
Competition hybridization by "pre-saturation" of HeLa cell DNA.
Simian virus 40 early mRNA's in lytically infected and transformed cells contain six 5'-terminal caps.
在裂解感染和转化细胞中的猿猴病毒40早期信使核糖核酸含有六个5'-末端帽结构。
J Virol. 1981 Jan;37(1):7-16. doi: 10.1128/JVI.37.1.7-16.1981.
4
In vitro splicing of SV40 late mRNA in isolated nuclei from CV-1 cells.SV40晚期mRNA在来自CV-1细胞的分离细胞核中的体外剪接。
Nucleic Acids Res. 1980 Feb 11;8(3):587-99. doi: 10.1093/nar/8.3.587.
5
Leakage of nuclear transcripts late in simian virus 40-infected CV1 cells: quantitation of spliced and unspliced late 19S RNAs.猿猴病毒40感染的CV1细胞后期核转录本的泄漏：剪接和未剪接的晚期19S RNA的定量分析
J Virol. 1980 Nov;36(2):595-600. doi: 10.1128/JVI.36.2.595-600.1980.
6
5,6-dichloro-1-beta-ribofuranosylbenzimidazole enhances premature termination of late transcription of simian virus 40 DNA.5,6-二氯-1-β-D-呋喃核糖基苯并咪唑增强猿猴病毒40 DNA晚期转录的提前终止。
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3297-3301. doi: 10.1073/pnas.77.6.3297.
7
Topography of the three late mRNA's of polyoma virus which encode the virion proteins.编码病毒体蛋白的多瘤病毒三种晚期mRNA的拓扑结构。
J Virol. 1980 Feb;33(2):637-51. doi: 10.1128/JVI.33.2.637-651.1980.
8
The synthesis and processing of a nuclear RNA precursor to rat pregrowth hormone messenger RNA.大鼠生长激素前体信使核糖核酸核RNA前体的合成与加工
Nucleic Acids Res. 1979 Jul 11;6(9):3133-44. doi: 10.1093/nar/6.9.3133.
9
On pre-messenger RNA and transcriptions. A review.关于信使前体RNA与转录。一篇综述。
Mol Biol Rep. 1979 May 31;5(1-2):5-28. doi: 10.1007/BF00777484.
10
Gene localization by chromosome fractionation: globin genes are on at least two chromosomes and three estrogen-inducible genes are on three chromosomes.通过染色体分级分离进行基因定位：珠蛋白基因位于至少两条染色体上，三个雌激素诱导基因位于三条染色体上。
Proc Natl Acad Sci U S A. 1979 Mar;76(3):1348-52. doi: 10.1073/pnas.76.3.1348.
通过HeLa细胞DNA的“预饱和”进行竞争杂交。
J Mol Biol. 1969 Sep 28;44(3):551-62. doi: 10.1016/0022-2836(69)90379-9.
4
A dye-buoyant-density method for the detection and isolation of closed circular duplex DNA: the closed circular DNA in HeLa cells.一种用于检测和分离闭环双链DNA的染料浮力密度法：HeLa细胞中的闭环DNA
Proc Natl Acad Sci U S A. 1967 May;57(5):1514-21. doi: 10.1073/pnas.57.5.1514.
5
Cleavage of Simian virus 40 DNA at a unique site by a bacterial restriction enzyme.猿猴病毒40 DNA在一个独特位点被一种细菌限制酶切割。
Proc Natl Acad Sci U S A. 1972 Nov;69(11):3365-9. doi: 10.1073/pnas.69.11.3365.
6
Specificity of the break produced by restricting endonuclease R 1 in Simian virus 40 DNA, as revealed by partial denaturation mapping.通过部分变性图谱揭示限制内切酶R 1对猿猴病毒40 DNA产生的断裂的特异性。
Proc Natl Acad Sci U S A. 1972 Nov;69(11):3215-9. doi: 10.1073/pnas.69.11.3215.
7
Selective extraction of polyoma DNA from infected mouse cell cultures.从受感染的小鼠细胞培养物中选择性提取多瘤病毒DNA。
J Mol Biol. 1967 Jun 14;26(2):365-9. doi: 10.1016/0022-2836(67)90307-5.
8
Mutants of simian virus 40 differing in plaque size, oncogenicity, and heat sensitivity.猿猴病毒40在噬斑大小、致癌性和热敏感性方面存在差异的突变体。
J Bacteriol. 1966 Oct;92(4):990-4. doi: 10.1128/jb.92.4.990-994.1966.
9
Clustering of the DNA sequences complementary to repetitive nuclear RNA of HeLa cells.与海拉细胞重复核RNA互补的DNA序列的聚类
J Mol Biol. 1975 Mar 25;93(1):23-38. doi: 10.1016/0022-2836(75)90357-5.
10
A specific endonuclease from Haemophilus haemolyticus.一种来自溶血嗜血杆菌的特异性核酸内切酶。
J Mol Biol. 1976 May 5;103(1):199-208. doi: 10.1016/0022-2836(76)90060-7.