Tütüncü E Ediz, Gurbuz Yunus, Ozturk Baris, Kuscu Ferit, Sencan Irfan
Department of Clinical Microbiology and Infectious Diseases, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.
Scand J Infect Dis. 2010 May;42(5):385-8. doi: 10.3109/00365540903501624.
Crimean-Congo haemorrhagic fever (CCHF) is an acute disease affecting multiple organ systems and is characterized by fever and haemorrhages. The pathogenesis of CCHF has not been well described. Nitric oxide (NO) is an important regulator of a number of different biological processes and can participate in antimicrobial defence. In this study, we measured the level of NO in the serum of patients with CCHF and healthy controls to define the possible role of NO in the control of infection. Sixty-two patients with CCHF and 31 controls were included in the study. NO levels in CCHF patients and the control group were found to be a mean of 40.49 microM (standard deviation (SD) 23.00) and 14.89 microM (SD 7.94), respectively. NO levels were significantly higher in CCHF patients with respect to controls (p < 0.001). NO levels in the patients with non-fatal CCHF and fatal CCHF were compared and found to be a mean of 43.57 microM (SD 22.70) and 26.23 microM (SD 19.43), respectively; this difference was statistically significant (p=0.009). In conclusion, elevated levels of NO may play a protective role in CCHF.
克里米亚-刚果出血热（CCHF）是一种影响多个器官系统的急性疾病，其特征为发热和出血。CCHF的发病机制尚未得到充分描述。一氧化氮（NO）是多种不同生物过程的重要调节因子，可参与抗菌防御。在本研究中，我们测量了CCHF患者和健康对照者血清中的NO水平，以确定NO在控制感染中的可能作用。该研究纳入了62例CCHF患者和31名对照者。发现CCHF患者和对照组的NO水平分别平均为40.49微摩尔（标准差（SD）23.00）和14.89微摩尔（SD 7.94）。CCHF患者的NO水平相对于对照组显著更高（p < 0.001）。对非致命性CCHF患者和致命性CCHF患者的NO水平进行了比较，发现分别平均为43.57微摩尔（SD 22.70）和26.23微摩尔（SD 19.43）；这种差异具有统计学意义（p = 0.009）。总之，NO水平升高可能在CCHF中发挥保护作用。
