Instituto de Investigación en Recursos Cinegéticos, IREC (CSIC, UCLM, JCCM), Ciudad Real, Spain.
Reprod Toxicol. 2010 Jun;29(3):346-52. doi: 10.1016/j.reprotox.2010.01.005. Epub 2010 Jan 21.
Lowered sperm quality associated with reduced superoxide dismutase activity in testis and spermatozoa has been observed in red deer from a mined area in South-central Spain. Here we present fatty acid profiles for testis and spermatozoa of deer from this mined area (n=29) and a control area (n=33). Despite elevated Pb in liver and bone of red deer from this area, concentrations in testis and sperm were not significantly higher than in control areas; however, Cu in testis was lower in mined areas. Testis from mined areas also contained higher percentages of linoleic acid (18:2n-6) and dihomo-gamma-linolenic acid (20:3n-6), but lower arachidonic acid (20:4n-6). The percentage of 20:4n-6 was also lower in spermatozoa of deer from the mined area. Copper levels in testis correlated positively with the percentage of 20:4n-6. The imbalance in Cu homeostasis caused by metal pollution may have caused the observed effects on deer sperm.
在西班牙中南部的一个矿区，研究人员发现，红鹿的精子质量下降与睾丸和精子中超氧化物歧化酶活性降低有关。本研究提供了来自矿区（n=29）和对照区（n=33）的鹿睾丸和精子的脂肪酸图谱。尽管该地区的红鹿肝脏和骨骼中的铅含量升高，但睾丸和精子中的浓度并不明显高于对照区；然而，矿区睾丸中的铜含量较低。矿区的睾丸还含有更高比例的亚油酸（18:2n-6）和二高-γ-亚麻酸（20:3n-6），但花生四烯酸（20:4n-6）的比例较低。矿区鹿的精子中 20:4n-6 的比例也较低。睾丸中的铜水平与 20:4n-6 的百分比呈正相关。金属污染引起的铜内稳态失衡可能导致了鹿精子的这种变化。
