有毒痕量金属与体外受精（IVF）期间的人类卵母细胞。
Toxic trace metals and human oocytes during in vitro fertilization (IVF).
机构信息
Department of Environmental Health Sciences, University at Albany, State University of New York, Rensselaer, NY 12144, USA.
出版信息
Reprod Toxicol. 2010 Jun;29(3):298-305. doi: 10.1016/j.reprotox.2010.01.003. Epub 2010 Jan 22.
Abstract
Trace exposures to the toxic metals mercury (Hg), cadmium (Cd) and lead (Pb) may threaten human reproductive health. The aim of this study is to generate biologically-plausible hypotheses concerning associations between Hg, Cd, and Pb and in vitro fertilization (IVF) endpoints. For 15 female IVF patients, a multivariable log-binomial model suggests a 75% reduction in the probability for a retrieved oocyte to be in metaphase-II arrest for each microg/dL increase in blood Pb concentration (relative risk (RR)=0.25, 95% confidence interval (CI) 0.03-2.50, P=0.240). For 15 male IVF partners, each microg/L increase in urine Cd concentration is associated with an 81% decrease in the probability for oocyte fertilization (RR=0.19, 95% CI 0.03-1.35, P=0.097). Because of the magnitude of the effects, these results warrant a comprehensive study with sufficient statistical power to further evaluate these hypotheses.
摘要
痕量接触有毒金属汞（Hg）、镉（Cd）和铅（Pb）可能会威胁到人类的生殖健康。本研究的目的是提出与 Hg、Cd 和 Pb 与体外受精（IVF）终点相关的生物学上合理的假说。对于 15 名接受 IVF 的女性患者，多变量对数二项式模型表明，血液 Pb 浓度每增加 1μg/dL，中期 II 阻滞的卵母细胞的概率降低 75%（相对风险（RR）=0.25，95%置信区间（CI）0.03-2.50，P=0.240）。对于 15 名男性 IVF 伴侣，尿液 Cd 浓度每增加 1μg/L，卵母细胞受精的概率降低 81%（RR=0.19，95%CI 0.03-1.35，P=0.097）。由于这些影响的幅度很大，因此需要进行一项具有足够统计效力的全面研究，以进一步评估这些假说。
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