Department of Epidemiology, University at Albany, State University of New York, Rensselaer, NY, USA.
J Assist Reprod Genet. 2010 Aug;27(8):463-8. doi: 10.1007/s10815-010-9437-0. Epub 2010 May 27.
We recently reported evidence suggesting associations between urine cadmium concentrations, reflecting long-term exposure, measured in 25 female patients (relative risk = 1.41, P = 0.412) and 15 of their male partners (relative risk = 0.19, P = 0.097) and oocyte fertilization in vitro. Blood cadmium concentrations reflect more recent exposure.
We here incorporate those measures into our prior data set and employ multivariable log-binomial regression models to generate hypotheses concerning the relative effects of long-term and recent cadmium exposure on oocyte fertilization in vitro.
No association is indicated for blood cadmium from women and oocyte fertilization, adjusted for urine cadmium and creatinine, blood lead and mercury, age, race/ethnicity and cigarette smoking (relative risk = 0.88, P = 0.828). However, we suggest an inverse adjusted association between blood cadmium from men and oocyte fertilization (relative risk = 0.66, P = 0.143).
These results suggest that consideration of long-term and recent exposures are both important for assessing the effect of partner cadmium levels on oocyte fertilization in vitro.
我们最近报告的证据表明，25 名女性患者（相对风险=1.41，P=0.412）和 15 名男性患者尿液中反映长期暴露的镉浓度（相对风险=0.19，P=0.097）与体外卵母细胞受精有关。血液中的镉浓度反映了最近的暴露情况。
我们将这些措施纳入之前的数据集中，并采用多变量对数二项式回归模型，对长期和近期镉暴露对体外卵母细胞受精的相对影响生成假设。
调整了尿液镉和肌酐、血铅和汞、年龄、种族/民族和吸烟情况后，来自女性的血液镉与卵母细胞受精之间没有关联（相对风险=0.88，P=0.828）。然而，我们提示来自男性的血液镉与卵母细胞受精之间存在反向调整关联（相对风险=0.66，P=0.143）。
这些结果表明，在评估配偶体内镉水平对体外卵母细胞受精的影响时，同时考虑长期和近期暴露情况非常重要。
