New York University Fertility Center, New York University School of Medicine, New York, New York 10016, USA.
Fertil Steril. 2010 May 1;93(7):2413.e7-9. doi: 10.1016/j.fertnstert.2009.12.004. Epub 2010 Jan 25.
To report the use of previously cryopreserved oocytes for the treatment of secondary infertility.
Case report.
University-based IVF program.
PATIENT(S): A 41-year-old woman with 18 months of secondary infertility and a previous history (age 38) of elective oocyte cryopreservation.
INTERVENTION(S): Previously cryopreserved oocytes.
MAIN OUTCOME MEASURE(S): Fertilization, embryo development, pregnancy, and outcome.
RESULT(S): The patient achieved pregnancy and delivery following thaw of oocytes electively cryopreserved 39 months before use. Before thawing the oocyte, the patient attempted pregnancy naturally for 12 months, followed by two unsuccessful clomiphene citrate ovulation induction cycles with intrauterine insemination and one fresh IVF cycle resulting in a chromosomally abnormal twin gestation that aborted.
CONCLUSION(S): Although oocyte cryopreservation is still labeled an experimental procedure, this case demonstrates that oocyte cryopreservation used for electively deferred reproduction can subsequently serve in the treatment for secondary infertility when the patient becomes her own oocyte donor.
报告使用先前冷冻保存的卵母细胞治疗继发性不孕。
病例报告。
以大学为基础的体外受精计划。
一名 41 岁的女性，继发性不孕 18 个月，此前（38 岁时）有选择性卵母细胞冷冻保存史。
先前冷冻保存的卵母细胞。
受精、胚胎发育、妊娠和结局。
患者在使用前 39 个月选择性冷冻保存的卵母细胞解冻后成功妊娠并分娩。在解冻卵母细胞之前，患者尝试自然受孕 12 个月，随后进行了两次不成功的氯米芬枸橼酸排卵诱导宫内授精周期和一次新鲜的体外受精周期，导致染色体异常的双胞胎妊娠流产。
尽管卵母细胞冷冻保存仍被标记为实验性程序，但该病例表明，当患者成为自己的卵母细胞供体时，先前用于选择性推迟生殖的卵母细胞冷冻保存可随后用于治疗继发性不孕。
