Akçay Adnan Burak, Ozcan Türkay, Seyis Sabri, Acele Armağan
Department of Cardiology, Medicine Faculty of Mustafa Kemal University, Hatay, Turkey.
Turk Kardiyol Dern Ars. 2009 Oct;37(7):497-500.
Capsaicin is the active component of chili peppers, which has been shown to possess several beneficial effects. Currently, the best-known medical use of capsaicin is as a topical painkiller. Drug-induced myocardial infarction is not a common phenomenon and the underlying mechanism has been related with coronary spasm in the majority of cases. We present a 29-year-old man who experienced coronary vasospasm and acute myocardial infarction (AMI) which were possibly induced by the use of a topical capsaicin patch to relieve lumbago. He presented with chest pain of one hour onset. The electrocardiogram showed ST-segment elevation in the leads II, III, and aVF, consistent with inferior wall AMI. Echocardiography confirmed inferior hypokinesia. Urgent coronary angiography showed normal right and left coronary arteries. Since he had no cardiac risk factors for coronary artery disease, nor a history of recent emotional or physical stress, or ingestion of any illicit substance, the vasospasm and subsequent AMI was attributed to the use of the capsaicin patch for six days. Upon institution of appropriate treatment and removal of the patch, no new anginal attacks or ischemic episodes were seen within a follow-up of one month. This is the first case report of AMI induced by the use of a topical capsaicin patch.
辣椒素是辣椒的活性成分，已被证明具有多种有益作用。目前，辣椒素最广为人知的医学用途是作为一种局部止痛药。药物性心肌梗死并非常见现象，在大多数情况下，其潜在机制与冠状动脉痉挛有关。我们报告一名29岁男性，他经历了冠状动脉痉挛和急性心肌梗死（AMI），可能是由于使用局部辣椒素贴片缓解腰痛所致。他出现胸痛1小时。心电图显示II、III和aVF导联ST段抬高，符合下壁AMI。超声心动图证实下壁运动减弱。紧急冠状动脉造影显示左右冠状动脉正常。由于他没有冠状动脉疾病的心脏危险因素，近期也没有情绪或身体应激史，也没有摄入任何非法物质，因此血管痉挛及随后的AMI归因于使用辣椒素贴片6天。在采取适当治疗并移除贴片后，在1个月的随访中未出现新的心绞痛发作或缺血事件。这是首例关于使用局部辣椒素贴片诱发AMI的病例报告。
