Department of Ophthalmology, Mainz University Medical Center, Mainz, Germany.
Cornea. 2010 Mar;29(3):260-2. doi: 10.1097/ICO.0b013e3181b55cc1.
To describe the ultrasonographically detected central corneal thickness (CCT) in patients with Type II and VI mucopolysaccharidosis (MPS) and its impact on applanation tonometry and glaucoma detection.
Twenty-eight patients with MPS (19 MPS II, nine MPS VI) underwent pachymetric investigation of CCT. Additionally, ultrasound measurements of axial length of the globe, slit-lamp evaluation with semiquantitative grading of corneal clouding, applanation tonometry, and assessment of refractive error were performed.
Median average corneal thickness was 534.5 microm (range, 491.5-579.0 microm) in the MPS II and 547.0 microm (range, 492.5-693.05 microm) in the MPS VI group. CCT depended on degree of corneal clouding and patients' age, but did not correlate with intraocular pressure, refractive error, axial length, or MPS type. There were no substantial differences in refractive error between MPS II and MPS VI.
In our patients, CCT in MPS II and VI did not differ statistically significantly from age-related values found in healthy subjects. Thus, intraocular pressure readings detected by applanation tonometry in MPS II and VI in the majority of patients can be regarded as reliable. In the case of clinically marked corneal clouding, measurement of CCT is recommended to adequately assess intraocular pressure and possible coexistent glaucoma.
描述 II 型和 VI 型黏多糖贮积症（MPS）患者的超声检测中央角膜厚度（CCT）及其对压平眼压测量和青光眼检测的影响。
28 例 MPS 患者（19 例 MPS II，9 例 MPS VI）接受 CCT 厚度的测量。此外，还进行了眼球轴向长度的超声测量、角膜混浊的半定量分级裂隙灯检查、压平眼压测量以及屈光不正评估。
MPS II 组的平均角膜厚度中位数为 534.5 微米（范围，491.5-579.0 微米），MPS VI 组为 547.0 微米（范围，492.5-693.05 微米）。CCT 取决于角膜混浊程度和患者年龄，但与眼压、屈光不正、眼轴或 MPS 类型无关。MPS II 和 MPS VI 之间的屈光不正差异无统计学意义。
在我们的患者中，MPS II 和 VI 的 CCT 与健康受试者的年龄相关值没有统计学上的显著差异。因此，压平眼压测量在大多数 MPS II 和 VI 患者中检测到的眼压读数可以被认为是可靠的。在临床上明显的角膜混浊的情况下，建议测量 CCT，以充分评估眼压和可能并存的青光眼。
