Roux Bénédicte Gaillard-Le, Méchinaud Françoise, Gay-Andrieu Françoise, Lortholary Olivier, Dannaoui Eric, Hoinard Damien, Corradini Nadege
Pediatrics Oncology Department, Centre Hospitalier Universitaire Mère-Enfant, France.
J Pediatr Hematol Oncol. 2010 Mar;32(2):131-3. doi: 10.1097/MPH.0b013e3181ca0dcf.
Mucormycosis are opportunistic infections mostly observed in immunocompromised patients. We report the case of a 13-year-old girl who suffered a systemic mucormycosis without presenting the usual risk factors. She was undergoing antineoplastic chemotherapy for advanced osteosarcoma of the femur with an uncommunicative pathologic fracture and pulmonary metastasis. Absidia corymbifera was isolated from skin lesions at the primary tumor site. She subsequently developed fungal pulmonary localizations and blood vessel thrombosis. Surgical treatment together with systemic, high doses of liposomal amphotericin B, posaconazole, and caspofungin cured the local infection and controlled systemic lesions. Unfortunately, the break in chemotherapy led to pulmonary metastasis progression.
毛霉病是一种机会性感染，多见于免疫功能低下的患者。我们报告了一例13岁女孩的病例，她患有全身性毛霉病，但未出现常见的危险因素。她正在接受针对股骨晚期骨肉瘤伴隐匿性病理性骨折和肺转移的抗肿瘤化疗。从原发肿瘤部位的皮肤病变中分离出伞枝犁头霉。随后她出现了肺部真菌感染和血管血栓形成。手术治疗联合全身大剂量脂质体两性霉素B、泊沙康唑和卡泊芬净治愈了局部感染并控制了全身病变。不幸的是，化疗中断导致肺转移进展。
