Malfertheiner M V, Kandulski A, Malfertheiner P, Schreiber J
Fachbereich für Pneumologie, Otto-von-Guericke-Universität Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Deutschland.
Internist (Berl). 2010 Mar;51 Suppl 1:246-54. doi: 10.1007/s00108-009-2506-8.
Gastroesophageal reflux disease (GERD) is a common disease in the western world. Usually it occurs with typical symptoms like heartburn and regurgitation, but almost every third GERD-patient presents with extraesophageal symptoms and diseases in which a causal relation with GERD is discussed. The extraesophageal symptoms possibly associated with GERD are chronic cough, bronchial asthma, sleep disturbances including obstructive sleep apnea, hoarseness, dental erosions, non-cardiac chest pain and idiopathic pulmonary fibrosis. This article gives an overview of the reflux-associated diseases of the airways as well as the proposed pathomechanisms and therapeutic options.
胃食管反流病(GERD)在西方世界是一种常见疾病。通常它会出现烧心和反流等典型症状,但几乎每三分之一的GERD患者会出现食管外症状以及一些正在讨论其与GERD存在因果关系的疾病。可能与GERD相关的食管外症状包括慢性咳嗽、支气管哮喘、睡眠障碍(包括阻塞性睡眠呼吸暂停)、声音嘶哑、牙齿侵蚀、非心源性胸痛和特发性肺纤维化。本文概述了与反流相关的气道疾病以及提出的发病机制和治疗选择。