School of Chemical Sciences, Dublin City University, Dublin 9, Ireland.
J Am Chem Soc. 2010 Feb 17;132(6):2024-8. doi: 10.1021/ja9094439.
Stimuli-responsive gate mechanisms offer potential for the controlled passage of payload molecules from a porous carrier vehicle on-demand. We describe a method for the enzyme-mediated release of macromolecular guest molecules from inorganic silica particles coated with a bioactive peptide shell, synthesized precisely by Fmoc chemistry. Specific enzymatic hydrolysis of the peptide shell removes the bulky peptide-terminated Fmoc groups, permitting the selective release of previously entrapped guest molecules.
刺激响应式门控机制为按需从多孔载体中控制载药分子的传递提供了可能。我们描述了一种酶介导的方法，用于从涂有生物活性肽壳的无机硅粒子中释放大分子客体分子，该肽壳是通过 Fmoc 化学精确合成的。肽壳的特异性酶水解去除了庞大的肽端 Fmoc 基团，从而可以选择性地释放先前包埋的客体分子。
