Mohammadi Farzaneh, Razmjooei Nadia, Mohsenpour Mohammad Ali, Nejati Mohammad Ali, Eftekhari Mohammad Hassan, Hejazi Najmeh
Student Research Committee, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
BMC Nutr. 2025 Jan 7;11(1):3. doi: 10.1186/s40795-024-00989-w.
Probiotics play an important role in the control and treatment of non-alcoholic fatty liver disease (NAFLD). Kefir drink is a fermented beverage and has indicated some beneficial health effects. The aim of this study was to evaluate the effects of kefir drink on liver aminotransferases, anthropometric indices, glycemic index, lipid profile, blood pressure (BP), high sensitivity C-reactive protein, and malondialdehyde in patients with NAFLD.
In an 8-week randomized clinical trial, 80 patients with NAFLD were randomized into two groups of 40. After a 2-week run-in period, the groups received a dietary plan and dietary plan plus a cup of kefir drink twice a day (500 cc/d), respectively. Also, demographic, anthropometric, laboratory, BP, dietary intake, and physical activity assessments were analyzed before and after the intervention.
At last, seventy-two participants completed the study. No significant difference in changes in BP, anthropometric indices, and laboratory data (P > 0.05) except HDL-C (P = 0.02) and fat-free mass (P < 0.001) was observed between the two study groups.
Based on the results, Drinking 500 cc/d kefir beverage had no significant effect on liver aminotransferases and metabolic indicators, except for HDL-C and fat-free mass in patients with NAFLD.
IRCT20170916036204N6 (2018/08/03).
益生菌在非酒精性脂肪性肝病（NAFLD）的控制和治疗中发挥着重要作用。开菲尔饮品是一种发酵饮料，已显示出一些有益的健康效果。本研究的目的是评估开菲尔饮品对NAFLD患者肝脏转氨酶、人体测量指标、血糖指数、血脂谱、血压（BP）、高敏C反应蛋白和丙二醛的影响。
在一项为期8周的随机临床试验中，80例NAFLD患者被随机分为两组，每组40例。经过2周的导入期后，两组分别接受饮食计划以及饮食计划加每天两杯开菲尔饮品（500毫升/天）。此外，在干预前后对人口统计学、人体测量学、实验室检查、血压、饮食摄入和身体活动评估进行了分析。
最后，72名参与者完成了研究。两个研究组之间除高密度脂蛋白胆固醇（HDL-C，P = 0.02）和去脂体重（P < 0.001）外，血压、人体测量指标和实验室数据的变化无显著差异（P > 0.05）。
基于研究结果，每天饮用500毫升开菲尔饮品对NAFLD患者的肝脏转氨酶和代谢指标无显著影响，但对HDL-C和去脂体重有影响。
IRCT20170916036204N6（2018/08/03）。
