Steno Diabetes Center, Niels Steensens Vej 2, DK-2820 Gentofte, Denmark.
J Physiol. 2010 Mar 1;588(Pt 5):759-64. doi: 10.1113/jphysiol.2009.184028. Epub 2010 Jan 25.
The assessment of pancreatic beta cell function in humans is challenging because of a complex interplay between insulin secretion, insulin sensitivity and hepatic insulin extraction. Simplified, the relationship between insulin secretion and insulin sensitivity can be described by an approximate hyperbola with the product of the two variables being constant for individuals with the same degree of glucose tolerance (the disposition index). Strengths and limitations of the disposition index have been widely debated in the literature. In this review we will focus on another and until recently unrecognized dimension of the disposition index, namely the issue of adjusting insulin secretion for hepatic versus peripheral insulin sensitivity. An underlying assumption of this issue is that the liver as compared to muscle plays a different role in the regulation of in vivo insulin secretion.
在人体中评估胰岛β细胞功能具有挑战性，因为胰岛素分泌、胰岛素敏感性和肝胰岛素摄取之间存在复杂的相互作用。简化来说，胰岛素分泌和胰岛素敏感性之间的关系可以用一条近似的双曲线来描述，对于具有相同葡萄糖耐量的个体，两个变量的乘积是恒定的（处置指数）。在文献中，处置指数的优缺点已经进行了广泛的讨论。在这篇综述中，我们将重点关注处置指数的另一个、直到最近才被人们认识到的维度，即调整肝胰岛素敏感性与外周胰岛素敏感性相关的胰岛素分泌的问题。这个问题的一个基本假设是，与肌肉相比，肝脏在体内胰岛素分泌的调节中起着不同的作用。
