Department of Endocrinology and Metabolism, Charité - Universitätsmedizin Berlin, 10117, Berlin, Germany.
Berlin Institute of Health at Charité - Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Junior Digital Clinician Scientist Program, Charitéplatz 1, 10117, Berlin, Germany.
Nutr Diabetes. 2023 Sep 20;13(1):17. doi: 10.1038/s41387-023-00245-3.
5-Aminovaleric acid betaine (5-AVAB) has recently been identified as a diet and microbial-dependent factor inducing obesity and hepatic steatosis in mice fed a Western diet. Accumulating evidence suggests a role in metabolic dysfunction associated with obesity, diabetes, and fatty liver disease. However, whether 5-AVAB plays a role in human disease is unclear, and human data are sparse.
We measured circulating 5-AVAB serum levels in 143 individuals with overweight or obesity participating in a randomized intervention study (NCT00850629) investigating the long-term effect of a weight maintenance strategy after diet-induced weight reduction.
Higher 5-AVAB serum levels correlate with worse estimates of obesity, glucose metabolism, and hepatic steatosis after weight loss. Furthermore, higher 5-AVAB levels after weight loss independently predict detrimental changes in glucose metabolism 18 months after the successful weight reduction.
Our human data supports previous findings in rodents indicating a relevant, potentially disadvantageous function of 5-AVAB in the context of metabolic dysbalance.
5-氨基戊酸甜菜碱（5-AVAB）最近被确定为一种饮食和微生物依赖性因素，可诱导喂食西式饮食的小鼠肥胖和肝脂肪变性。越来越多的证据表明，它在与肥胖、糖尿病和脂肪肝疾病相关的代谢功能障碍中发挥作用。然而，5-AVAB 是否在人类疾病中发挥作用尚不清楚，且人类数据较少。
我们在 143 名超重或肥胖的个体中测量了循环中的 5-AVAB 血清水平，这些个体参加了一项随机干预研究（NCT00850629），该研究调查了饮食诱导减重后维持体重策略的长期效果。
减肥后，5-AVAB 血清水平较高与肥胖、葡萄糖代谢和肝脂肪变性的估计值较差相关。此外，减肥后 5-AVAB 水平升高可独立预测减重成功 18 个月后葡萄糖代谢的不利变化。
我们的人类数据支持先前在啮齿动物中的发现，表明 5-AVAB 在代谢失衡的情况下具有相关的、潜在不利的功能。
