意大利肉鸡群中产超广谱β-内酰胺酶大肠杆菌的高多样性。
High diversity of extended-spectrum beta-lactamases in Escherichia coli isolates from Italian broiler flocks.
机构信息
Department of Veterinary Disease Biology, University of Copenhagen, Stigbøjlen 4, 1870 Frederiksberg C, Denmark.
出版信息
Antimicrob Agents Chemother. 2010 Apr;54(4):1623-6. doi: 10.1128/AAC.01361-09. Epub 2010 Jan 25.
Abstract
We characterized 67 Escherichia coli isolates with reduced susceptibility to cefotaxime or ceftiofur obtained from healthy broilers housed in five Italian farms. The bla(CTX-M-1), bla(CTX-M-32) and bla(SHV-12) beta-lactamase genes were identified on IncI1, IncN, or IncFIB plasmids. Considerable genetic diversity was detected among the extended-spectrum beta-lactamase (ESBL)-producing isolates, and we identified indistinguishable strains in unrelated farms and indistinguishable plasmids in genetically unrelated strains. The detection of highly mobile plasmids suggests a potential animal reservoir for beta-lactamase genes.
摘要
我们对来自意大利五个农场的健康肉鸡中分离出的 67 株对头孢噻肟或头孢噻呋敏感性降低的大肠杆菌进行了研究。bla(CTX-M-1)、bla(CTX-M-32)和 bla(SHV-12)β-内酰胺酶基因位于 IncI1、IncN 或 IncFIB 质粒上。在产生超广谱β-内酰胺酶（ESBL）的分离株中检测到相当大的遗传多样性，我们在没有关联的农场中发现了相同的菌株，在遗传上没有关联的菌株中发现了相同的质粒。高度移动质粒的检测表明β-内酰胺酶基因可能存在于动物库中。
相似文献
1
High diversity of extended-spectrum beta-lactamases in Escherichia coli isolates from Italian broiler flocks.意大利肉鸡群中产超广谱β-内酰胺酶大肠杆菌的高多样性。
Antimicrob Agents Chemother. 2010 Apr;54(4):1623-6. doi: 10.1128/AAC.01361-09. Epub 2010 Jan 25.
2
Characterization of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli obtained from Danish pigs, pig farmers and their families from farms with high or no consumption of third- or fourth-generation cephalosporins.从丹麦猪、养猪户及其家庭成员中获取的产超广谱β-内酰胺酶（ESBL）大肠杆菌的特性分析，这些样本来自三代或四代头孢菌素高消费或无消费的农场。
J Antimicrob Chemother. 2014 Oct;69(10):2650-7. doi: 10.1093/jac/dku180. Epub 2014 Jun 7.
3
Molecular characterization of resistance to extended-spectrum cephalosporins in clinical Escherichia coli isolates from companion animals in the United States.美国宠物临床分离的大肠埃希菌对扩展谱头孢菌素耐药性的分子特征
Antimicrob Agents Chemother. 2011 Dec;55(12):5666-75. doi: 10.1128/AAC.00656-11. Epub 2011 Sep 26.
4
Prevalence and characterisation of CTX-M β-lactamases amongst Escherichia coli isolates from healthy food animals in China.中国健康食用动物源大肠埃希菌中产 CTX-M 型β-内酰胺酶的流行情况及特征。
Int J Antimicrob Agents. 2012 Apr;39(4):305-10. doi: 10.1016/j.ijantimicag.2011.12.001. Epub 2012 Feb 9.
5
Diversity of plasmid replicons encoding the bla(CMY-2) gene in broad-spectrum cephalosporin-resistant Escherichia coli from livestock animals in Japan.日本家畜动物中广谱头孢菌素耐药大肠杆菌携带 bla(CMY-2) 基因的质粒复制子多样性。
Foodborne Pathog Dis. 2013 Mar;10(3):243-9. doi: 10.1089/fpd.2012.1306.
6
Prevalence and characterization of extended-spectrum beta-lactamase (ESBL)- and CMY-2-producing Escherichia coli isolates from healthy food-producing animals in Tunisia.突尼斯健康食用动物中产超广谱β-内酰胺酶（ESBL）和 CMY-2 的大肠杆菌分离株的流行情况及特征。
Foodborne Pathog Dis. 2012 Dec;9(12):1137-42. doi: 10.1089/fpd.2012.1267. Epub 2012 Nov 29.
7
Subgrouping of ESBL-producing Escherichia coli from animal and human sources: an approach to quantify the distribution of ESBL types between different reservoirs.来自动物和人类源的产超广谱β-内酰胺酶大肠杆菌的亚群分析：一种量化不同宿主中超广谱β-内酰胺酶类型分布的方法。
Int J Med Microbiol. 2014 Oct;304(7):805-16. doi: 10.1016/j.ijmm.2014.07.015. Epub 2014 Aug 2.
8
Increased detection of extended spectrum beta-lactamase producing Salmonella enterica and Escherichia coli isolates from poultry.从家禽中检测到更多的产超广谱β-内酰胺酶的沙门氏菌和大肠杆菌分离株。
Vet Microbiol. 2010 Oct 26;145(3-4):273-8. doi: 10.1016/j.vetmic.2010.03.019. Epub 2010 Mar 27.
9
Extended-spectrum-β-lactamase- and AmpC-β-lactamase-producing Escherichia coli in Dutch broilers and broiler farmers.产超广谱β-内酰胺酶和 AmpCβ-内酰胺酶的大肠杆菌在荷兰肉鸡和肉鸡养殖户中的流行情况。
J Antimicrob Chemother. 2013 Jan;68(1):60-7. doi: 10.1093/jac/dks349. Epub 2012 Sep 4.
10
IncN plasmids carrying bla CTX-M-1 in Escherichia coli isolates on a dairy farm.在一个奶牛场的大肠杆菌分离株中携带 bla CTX-M-1 的 IncN 质粒。
Vet Microbiol. 2011 May 5;149(3-4):513-6. doi: 10.1016/j.vetmic.2010.11.032. Epub 2010 Dec 8.
引用本文的文献
1
Interplay between bacterial clones and plasmids in the spread of - and -carrying from the livestock environment.携带β-内酰胺酶和碳青霉烯酶的细菌克隆与质粒在畜牧环境中的传播相互作用。
One Health. 2025 May 24;20:101058. doi: 10.1016/j.onehlt.2025.101058. eCollection 2025 Jun.
2
Prevalence of ESBL-Resistant Genes in Birds in Italy-A Comprehensive Review.意大利鸟类中耐超广谱β-内酰胺酶基因的流行情况——一项综合综述
Animals (Basel). 2025 May 29;15(11):1598. doi: 10.3390/ani15111598.
3
Widespread prevalence of plasmid-mediated blaCTX-M type extended-spectrum beta-lactamase Escherichia coli in backyard broiler production systems in the United States.美国后院式肉鸡生产系统中广泛流行质粒介导的 blaCTX-M 型超广谱β-内酰胺酶大肠杆菌。
PLoS One. 2024 Jun 3;19(6):e0304599. doi: 10.1371/journal.pone.0304599. eCollection 2024.
4
Swine Colibacillosis: Global Epidemiologic and Antimicrobial Scenario.猪大肠杆菌病：全球流行病学与抗菌药物情况
Antibiotics (Basel). 2023 Mar 30;12(4):682. doi: 10.3390/antibiotics12040682.
5
Antimicrobial Resistance in from the Broiler Farm Environment, with Detection of SHV-12-Producing Isolates.肉鸡养殖场环境中的抗菌药物耐药性，兼产SHV-12分离株的检测
Antibiotics (Basel). 2022 Mar 25;11(4):444. doi: 10.3390/antibiotics11040444.
6
Genomic Epidemiology Insights on NDM-Producing Pathogens Revealed the Pivotal Role of Plasmids on Transmission.基因组流行病学研究揭示了产 NDM 病原体的关键作用，发现质粒在传播过程中发挥了关键作用。
Microbiol Spectr. 2022 Apr 27;10(2):e0215621. doi: 10.1128/spectrum.02156-21. Epub 2022 Feb 28.
7
Investigating the relationship between extended spectrum β-lactamase producing in the environment and food chains with the presence of this infection in people suspected of septicemia: Using the fuzzy set qualitative comparative analysis.利用模糊集定性比较分析法研究环境和食物链中产生超广谱β-内酰胺酶与疑似败血症患者感染情况之间的关系。
J Environ Health Sci Eng. 2020 Oct 25;18(2):1509-1520. doi: 10.1007/s40201-020-00567-9. eCollection 2020 Dec.
8
Snapshot Study of Whole Genome Sequences of from Healthy Companion Animals, Livestock, Wildlife, Humans and Food in Italy.意大利健康伴侣动物、家畜、野生动物、人类及食物全基因组序列的快照研究
Antibiotics (Basel). 2020 Nov 6;9(11):782. doi: 10.3390/antibiotics9110782.
9
Emergence of in Diseased Pigs in South Korea.韩国患病猪中[某种情况]的出现。 （你提供的原文中“Emergence of in”这里应该有具体所指内容缺失了）
Microorganisms. 2020 Oct 6;8(10):1538. doi: 10.3390/microorganisms8101538.
10
High occurrence of CMY-2-type beta-lactamase-producing Escherichia coli among broiler flocks in Turkey.土耳其肉鸡群中产CMY-2型β-内酰胺酶大肠杆菌的高发生率。
Trop Anim Health Prod. 2020 Jul;52(4):1681-1689. doi: 10.1007/s11250-019-02167-8. Epub 2019 Dec 19.
本文引用的文献
1
Distribution and possible transmission of ampicillin- and nalidixic acid-resistant Escherichia coli within the broiler industry.鸡场中氨苄青霉素和萘啶酸耐药大肠杆菌的分布和可能传播。
Vet Microbiol. 2010 May 19;142(3-4):379-86. doi: 10.1016/j.vetmic.2009.10.024. Epub 2009 Nov 6.
2
Resistance plasmid families in Enterobacteriaceae.肠杆菌科中的耐药性质粒家族。
Antimicrob Agents Chemother. 2009 Jun;53(6):2227-38. doi: 10.1128/AAC.01707-08. Epub 2009 Mar 23.
3
Transmission of IncN plasmids carrying blaCTX-M-1 between commensal Escherichia coli in pigs and farm workers.携带blaCTX-M-1的IncN质粒在猪的共生大肠杆菌与农场工人之间的传播。
Antimicrob Agents Chemother. 2009 Apr;53(4):1709-11. doi: 10.1128/AAC.01014-08. Epub 2009 Feb 2.
4
Characterization of plasmids encoding blaESBL and surrounding genes in Spanish clinical isolates of Escherichia coli and Klebsiella pneumoniae.西班牙临床分离的大肠杆菌和肺炎克雷伯菌中编码超广谱β-内酰胺酶（blaESBL）及其周围基因的质粒的特征分析
J Antimicrob Chemother. 2009 Jan;63(1):60-6. doi: 10.1093/jac/dkn453. Epub 2008 Nov 6.
5
Replicon typing of plasmids in Escherichia coli producing extended-spectrum beta-lactamases.产超广谱β-内酰胺酶大肠杆菌中质粒的复制子分型
J Antimicrob Chemother. 2009 Jan;63(1):67-71. doi: 10.1093/jac/dkn428. Epub 2008 Oct 18.
6
Multilocus sequence typing of IncI1 plasmids carrying extended-spectrum beta-lactamases in Escherichia coli and Salmonella of human and animal origin.对人和动物源大肠杆菌及沙门氏菌中携带超广谱β-内酰胺酶的IncI1质粒进行多位点序列分型。
J Antimicrob Chemother. 2008 Jun;61(6):1229-33. doi: 10.1093/jac/dkn131. Epub 2008 Mar 26.
7
Prevalence and spread of extended-spectrum beta-lactamase-producing Enterobacteriaceae in Europe.欧洲产超广谱β-内酰胺酶肠杆菌科细菌的流行情况与传播
Clin Microbiol Infect. 2008 Jan;14 Suppl 1:144-53. doi: 10.1111/j.1469-0691.2007.01850.x.
8
Animal reservoirs for extended spectrum beta-lactamase producers.产超广谱β-内酰胺酶细菌的动物宿主。
Clin Microbiol Infect. 2008 Jan;14 Suppl 1:117-23. doi: 10.1111/j.1469-0691.2007.01851.x.
9
Extended-spectrum beta-lactamase CTX-M-1 in Escherichia coli isolates from healthy poultry in France.法国健康家禽分离出的大肠杆菌中存在的超广谱β-内酰胺酶CTX-M-1
Appl Environ Microbiol. 2007 Jul;73(14):4681-5. doi: 10.1128/AEM.02491-06. Epub 2007 May 18.
10
Emergence and dissemination of Enterobacteriaceae isolates producing CTX-M-1-like enzymes in Spain are associated with IncFII (CTX-M-15) and broad-host-range (CTX-M-1, -3, and -32) plasmids.在西班牙，产CTX-M-1样酶的肠杆菌科分离株的出现和传播与IncFII（CTX-M-15）和广宿主范围（CTX-M-1、-3和-32）质粒有关。
Antimicrob Agents Chemother. 2007 Feb;51(2):796-9. doi: 10.1128/AAC.01070-06. Epub 2006 Dec 4.
Zotero 插件