Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Adv Exp Med Biol. 2021;1345:71-84. doi: 10.1007/978-3-030-82735-9_7.
Small intestinal submucosa (SIS) is the most studied extracellular matrix (ECM) for repair and regeneration of different organs and tissues. Promising results of SIS-ECM as a vascular graft, led scientists to examine its applicability for repairing other tissues. Overall results indicated that SIS grafts induce tissue regeneration and remodeling to almost native condition. Investigating immunomodulatory effects of SIS is another interesting field of research. SIS can be utilized in different forms for multiple clinical and experimental studies. The aim of this chapter is to investigate the decellularization process of SIS and its common clinical application.
小肠黏膜下层（SIS）是研究最多的用于修复和再生不同器官和组织的细胞外基质（ECM）。SIS-ECM 作为血管移植物的有前景的结果，促使科学家们研究其在修复其他组织中的适用性。总体结果表明，SIS 移植物可诱导组织再生和重塑，几乎达到原生状态。研究 SIS 的免疫调节作用是另一个有趣的研究领域。SIS 可以以不同的形式用于多种临床和实验研究。本章的目的是研究 SIS 的脱细胞过程及其常见的临床应用。
