基于胶原蛋白的生物材料在慢性伤口愈合及运动医学应用中的作用
The Role of Collagen-Based Biomaterials in Chronic Wound Healing and Sports Medicine Applications.
作者信息
Yeung David A, Kelly Natalie H
机构信息
Smith+Nephew Inc., 1450 Brooks Road, Memphis, TN 38116, USA.
出版信息
Bioengineering (Basel). 2021 Jan 8;8(1):8. doi: 10.3390/bioengineering8010008.
Abstract
Advancements in tissue engineering have taken aim at treating tissue types that have difficulty healing naturally. In order to achieve improved healing conditions, the balance of exogenous matrix, cells, and different factors must be carefully controlled. This review seeks to explore the aspects of tissue engineering in specific tissue types treated in sports medicine and advanced wound management from the perspective of the matrix component. While the predominant material to be discussed is collagen I, it would be remiss not to mention its relation to the other contributing factors to tissue engineered healing. The main categories of materials summarized here are (1) reconstituted collagen scaffolds, (2) decellularized matrix tissue, and (3) non-decellularized tissue. These three groups are ordered by their increase in additional components beyond simply collagen.
摘要
组织工程学的进展旨在治疗自然愈合困难的组织类型。为了实现更好的愈合条件，必须仔细控制外源性基质、细胞和不同因子之间的平衡。本综述旨在从基质成分的角度探讨运动医学和高级伤口管理中特定组织类型的组织工程学方面。虽然本文主要讨论的材料是I型胶原蛋白，但不提及它与组织工程愈合的其他促成因素之间的关系是疏忽的。这里总结的主要材料类别有：（1）重组胶原蛋白支架，（2）脱细胞基质组织，（3）非脱细胞组织。这三组是按照它们除了单纯胶原蛋白之外额外成分的增加来排序的。
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